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2D Metal-Oxide Nanosheets as a Homogeneous Li-Ion Flux Regulator for High-Performance Anodeless Lithium Metal Batteries.
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School of Mechanical Engineering and Department of Smart Fab. Technology, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419, Republic of Korea.
The anodeless battery design has recently gained significant interest by eliminating the direct use of a thick lithium (Li) foil. However, it suffers from inhomogeneous Li flux, resulting in dendrite growth and a short cycling life. To address this, the exfoliation of layered-structure titanium oxide to 2D nanosheets (2DTiO) is proposed to precisely control Li flux at the atomic scale by maximizing Li affinitive Ti sites.
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College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Article Synopsis
- The study synthesized various dimethoxy and methylenedioxy cinnamamide derivatives with tertiary amine groups and evaluated their ability to inhibit cholinesterase and penetrate the blood-brain barrier (BBB).
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Milk Quality Improvement Program, Department of Food Science, Cornell University, Ithaca, NY 14853. Electronic address:
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Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 50005, Hradec Králové, Czech Republic. Electronic address:
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View Article and Find Full Text PDFDiscovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles.
Eur J Med Chem
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Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China. Electronic address:
Taking our previously reported HIV-1 NNRTIs BH-11c and XJ-10c as lead compounds, series of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles were designed to improve anti-resistance and drug-like profiles. According to the three rounds of in vitro antiviral activity screening, compound 12g was the most active inhibitor against wild-type and five prevalent NNRTI-resistant HIV-1 strains with EC values ranging from 0.024 to 0.
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