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Background: Prescription for inappropriate drugs can be dangerous to very old people, due to the increased risk of adverse drug reactions.
Case Report: We report the consequences of inappropriate prescriptions in a 99-year-old woman. She had a clinical history of vascular dementia, diabetes, hypothyroidism, heart failure, osteoarthritis, chronic renal failure, and hypoacusia, and was admitted to our attention for asthenia and loss of appetite.
Article Synopsis
- The study examines how chronic exposure to digoxin affects locomotor activity and brain chemistry in zebrafish.
- Zebrafish were housed in groups and exposed to 2 μM of digoxin for a week, resulting in increased hyperactivity and decreased anxiety in a novel environment test.
- The findings reveal significant changes in brain monoamine levels, indicating that cardiotonic steroids like digoxin can influence neurotransmission, which might have implications for neuropsychiatric conditions.
Acute oral digoxin in healthy adults hastens fatigue and increases plasma K during intense exercise, despite preserved skeletal muscle Na,K-ATPase.
J Physiol
December 2024
Institute for Health and Sport, Victoria University, Melbourne, Australia.
Article Synopsis
- - The study examined how the Na,K-ATPase inhibitor digoxin affects muscle content, potassium levels, and fatigue during intense exercise in healthy adults, using a double-blind crossover design with a placebo.
- - Results showed that while muscle Na,K-ATPase binding increased with digoxin treatment, muscle isoform levels did not change, suggesting a potential adaptation mechanism to maintain Na,K-ATPase function despite the drug's effects.
- - Exercise produced significant shifts in potassium levels, with digoxin leading to earlier fatigue and altered potassium responses compared to the placebo, highlighting digoxin's impact on muscle performance during high-intensity activities.
Physiologically Based Pharmacokinetic Modeling to Assess Ritonavir-Digoxin Interactions and Recommendations for Co-Administration Regimens.
Pharm Res
November 2024
Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, Anhui, China.
Background: Digoxin is a commonly used cardiac glycoside drug in clinical practice, primarily transported by P-glycoprotein (P-gp) and susceptible to the influence of P-gp inhibitors/inducers. Concurrent administration of ritonavir and digoxin may significantly increase the plasma concentration of digoxin. Due to the narrow therapeutic window of digoxin, combined use may lead to severe toxic effects.
View Article and Find Full Text PDF[Early measurement of digoxin concentration in blood serum to predict adverse events in older age groups with chronic heart failure and atrial fibrillation.].
Adv Gerontol
November 2024
Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dinamo pr., St. Petersburg 197110, Russian Federation, e-mail:
To evaluate the effect of early measurement of serum digoxin concentration (SDC) on therapeutical safety and efficacy in patients with recent-onset atrial fibrillation and heart failure. De novo ventricular arrhythmias, high-grade AV node or sinus node blocks were noted in 22%, this risk was positively associated with endpoint SDC (mean SDC 0,88±0,78 ng/mL vs 0,45±0,71 ng/mL, p=0,039) irrespective of baseline characteristics. Empiric calculators for long-term digoxin monitoring correlated with both SDC (r=0,54.
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