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The black hole low-mass X-ray binary V404 Cygni is part of a wide triple.
Nature
November 2024
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Evidence suggests that, when compact objects such as black holes and neutron stars form, they may receive a 'natal kick', during which the stellar remnant gains momentum. Observational evidence for neutron star kicks is substantial, yet is limited for black hole natal kicks, and some proposed black hole formation scenarios result in very small kicks. Here we report that the canonical black hole low-mass X-ray binary (LMXB) V404 Cygni is part of a wide hierarchical triple with a tertiary companion at least 3,500 astronomical units (AU) away from the inner binary.
View Article and Find Full Text PDFA sequential binding mechanism for 5' splice site recognition and modulation for the human U1 snRNP.
Nat Commun
October 2024
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Article Synopsis
- Splice site recognition plays a crucial role in defining the transcriptome, and drugs like risdiplam and branaplam can modify how U1 snRNP recognizes specific 5' splice sites (5'SS).
- This research identifies a sequential binding mechanism for how branaplam influences the modulation of -1A bulged 5'SS, using advanced techniques like ensemble kinetic measurements and CoSMoS.
- The findings show that branaplam binds to the complex only after U1 snRNP engages with a 5'SS, impacting the formation of stable U1 snRNP/5'SS complexes, highlighting that branaplam interacts with ribonucleoprotein rather than just RNA.
Mechanistic insights into ligand dissociation from the SARS-CoV-2 spike glycoprotein.
PLoS Comput Biol
March 2024
Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, United States of America.
The COVID-19 pandemic, driven by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spurred an urgent need for effective therapeutic interventions. The spike glycoprotein of the SARS-CoV-2 is crucial for infiltrating host cells, rendering it a key candidate for drug development. By interacting with the human angiotensin-converting enzyme 2 (ACE2) receptor, the spike initiates the infection of SARS-CoV-2.
View Article and Find Full Text PDFAntivesiculation and Complete Unbinding of Tail-Tethered Lipids.
Langmuir
January 2024
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.
We report the effect of tail-tethering on vesiculation and complete unbinding of bilayered membranes. Amphiphilic molecules of a bolalipid, resembling the tail-tethered molecular structure of archaeal lipids, with two identical zwitterionic phosphatidylcholine headgroups self-assemble into a large flat lamellar membrane, in contrast to the multilamellar vesicles (MLVs) observed in its counterpart, monopolar nontethered zwitterionic lipids. The antivesiculation is confirmed by small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cyro-TEM).
View Article and Find Full Text PDFStructure and dynamics of whole-sequence homology model of ORF3a protein of SARS-CoV-2: An insight from microsecond molecular dynamics simulations.
J Biomol Struct Dyn
August 2024
Department of Chemistry and Biochemistry, Kennesaw State University, Kennesaw, GA, USA.
The ORF3a is a large accessory protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which plays an important role in virulence and viral replication; especially in inflammasome activation and apoptosis. However,, the existing cryo-EM structure of SARS-CoV-2 ORF3a is incomplete, . making it challenging to understand its structural and functional features.
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