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Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.
Mol Med
January 2025
Department of Critical Care Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, 430060, Hubei, China.
Background: Macrophages play an important role in the pathogenesis of ulcerative colitis (UC). We will explore the effects of sodium butyrate (SB) on macrophage function.
Methods: The targets of butyric acid were identified using SwissTargetPrediction database and surface plasmon resonance (SPR).
A pre-rule for the sequential probability ratio test in a between-item grid multidimensional computerized classification test.
Behav Res Methods
January 2025
Institute of Learning Sciences and Technologies, National Tsing Hua University, Hsinchu, 300044, Taiwan.
The measurement efficiency of a grid multidimensional computerized classification test (grid MCCT), which makes a classification decision per dimension, can be improved by taking the correlations between the dimensions into account in the termination criterion. The higher the correlations, the better the improvement in measurement efficiency. However, a termination criterion utilizing inter-dimensional information (i.
View Article and Find Full Text PDFLeveraging Model-Based Simulations to Optimize Extended Dosing of Leuprolide 6-Month Intramuscular Depot Formulation.
Eur J Drug Metab Pharmacokinet
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School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
Background And Objective: A gonadotropin-releasing hormone (GnRH) agonist such as leuprolide is widely used to achieve sustained suppression of testosterone levels, which play a critical role in the treatment of prostate cancer. Recent advances in drug delivery systems have led to the development of long-acting depot formulations, such as the 6-month intramuscular (IM) leuprolide formulation, which aim to simplify dosing and improve convenience for both patients and healthcare providers. Exploring extended dosing intervals for such formulations represents a promising approach to further optimize treatment regimens, potentially balancing efficacy with patient-centered care.
View Article and Find Full Text PDFA fluid flow model for the software defined wide area networks analysis.
Sci Rep
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Department of Distributed Systems and Informatic Devices, Gliwice, Poland.
The advancement of IT systems necessitates efficient communication methods essential across various sectors, from streaming platforms to cloud-based solutions and Industry 4.0 applications. Enhancing Quality of Service (QoS) in computer networks by focusing on bandwidth and communication delay is critical.
View Article and Find Full Text PDFUnderstanding collective behavior in biological systems through potential field mechanisms.
Sci Rep
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School of Electronics and Information Engineering, University of Science and Technology Liaoning, Anshan, 114051, China.
Collective behavior in biological systems emerges from local interactions among individuals, enabling groups to adapt to dynamic environments. Traditional modeling approaches, such as bottom-up and top-down models, have limitations in accurately representing these complex interactions. We propose a novel potential field mechanism that integrates local interactions and environmental influences to explain collective behavior.
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