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Time Dependent Effects of Cerebellar tDCS on Cerebello-cortical Connectivity Networks in Young Adults.
Cerebellum
January 2025
Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, USA.
The cerebellum is involved in non-motor processing, supported by topographically distinct cerebellar activations and closed-loop circuits between the cerebellum and the cortex. Disruptions to cerebellar function may negatively impact prefrontal function and processing. Cerebellar resources may be important for offloading cortical processing, providing crucial scaffolding for normative performance and function.
View Article and Find Full Text PDFDysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons.
Am J Physiol Cell Physiol
December 2024
Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Norway.
Amyotrophic lateral sclerosis (ALS) is characterized by dysfunction and loss of upper and lower motor neurons. Several studies have identified structural and functional alterations in the motor neurons before the manifestation of symptoms, yet the underlying cause of such alterations and how they contribute to the progressive degeneration of affected motor neuron networks remain unclear. Importantly, the short and long-term spatiotemporal dynamics of neuronal network activity make it challenging to discern how ALS-related network reconfigurations emerge and evolve.
View Article and Find Full Text PDFBacterial infection adversely increases the risk of decompensation in patients with hepatitis B virus-related compensated cirrhosis: a retrospective study.
BMC Infect Dis
December 2024
Department of Hepatology, Tianjin Second People's Hospital, Tianjin, China.
Article Synopsis
- * A study of 1,011 patients showed that those with bacterial infections had a much higher rate of progression to decompensated cirrhosis (44.9%) compared to those without infections (9%).
- * The research indicates that bacterial infections significantly increase the risk of worsening liver conditions in patients with compensated cirrhosis, highlighting the importance of monitoring and treating infections in these patients.
Medication Exposure and Mortality in Patients With Schizophrenia.
JAMA Netw Open
November 2024
Faculté de Pharmacie, Université Laval, Québec City, Québec, Canada.
Importance: The use of antipsychotics, antidepressants, and benzodiazepines may influence the risk of mortality in people with schizophrenia. However, many observational studies have not accounted for immortal time bias (ITB), which occurs when there is a period during which patients in the exposed group are necessarily alive and misclassified as exposed (the period between start of follow-up and initiation of drug). Ignoring ITB may lead to misinterpretation of the association between these drugs and mortality.
View Article and Find Full Text PDFEarly hepatic decompensation identifies patients with hepatocellular carcinoma treated with Atezolizumab plus Bevacizumab or Sorafenib at highest risk of death.
Clin Cancer Res
November 2024
University of Palermo, Palermo, Italy.
Article Synopsis
- This study examines how early clinical hepatic decompensation (CHD) affects the overall survival (OS) of patients with unresectable hepatocellular carcinoma (uHCC) who are receiving systemic treatments like Atezolizumab plus Bevacizumab or Sorafenib.
- Researchers analyzed data from the IMbrave150 trial and found that patients experiencing early CHD had a significantly higher risk of mortality, indicating a poor prognosis.
- The study identifies specific factors (like ALBI grade, INR levels, and macrovascular invasion) that put patients at a greater risk for CHD, suggesting that these could be useful in future clinical trials to better assess patient outcomes.
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