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Understanding and modeling of gas puff injection for diagnostic purposes.
Rev Sci Instrum
January 2025
Max-Planck-Institut für Plasmaphysik, Garching 85748, Germany.
This article presents an experimental setup capable of providing high spatial and temporal resolution measurements of neutral gas puff injection using a glow discharge to excite the neutral gas and an ultra-high-speed camera to record the emitted light. Using the proposed setup, the shape and propagation velocity of a thermal deuterium gas puff at 1 bar have been measured. The cloud has a conical shape and a propagation velocity of vprop = 1870 ± 270 m/s.
View Article and Find Full Text PDFGlucose Lowering through Weight management (GLoW): a randomised controlled trial of the clinical and cost effectiveness of a diabetes education and behavioural weight management programme vs a diabetes education programme in adults with a recent diagnosis of type 2 diabetes.
Diabetologia
January 2025
MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Aims/hypothesis: UK standard care for type 2 diabetes is structured diabetes education, with no effects on HbA, small, short-term effects on weight and low uptake. We evaluated whether remotely delivered tailored diabetes education combined with commercial behavioural weight management is cost-effective compared with current standard care in helping people with type 2 diabetes to lower their blood glucose, lose weight, achieve remission and improve cardiovascular risk factors.
Methods: We conducted a pragmatic, randomised, parallel two-group trial.
Operational lessons learned from simulating an elimination response to a transboundary animal disease in wild animals.
Prev Vet Med
January 2025
National Wildlife Research Center, USDA-APHIS, Fort Collins, CO 80521, USA.
Transboundary animal disease (TAD) introductions can have myriad economic, ecological, and societal impacts. When TADs are introduced into wild species, rapid and intense control efforts to reduce wild animal host populations are sometimes needed to eliminate the disease and prevent endemicity and spillover to domestic animal populations. Yet, such intensive efforts are non-trivial, and the rarity of TAD introductions means that personnel rarely have direct experience with these types of operations.
View Article and Find Full Text PDFSkin decontamination with and without water irrigation.
Disaster Med Public Health Prep
October 2024
Arizona Poison and Drug Information Center, College of Pharmacy, University of Arizona, Tucson, AZ, USA.
Objective: Rinsing only with water or washing with soap and water are common methods of skin decontamination for skin contaminated during a chemical hazard release. The null hypothesis was that a 15-minute water irrigation (decontamination method 1) would not be superior to decontamination using a microfiber towel, followed by a wet wipe (Signature Select Softly Flushable Tissue Better Living Brands LLC, Pleasanton, CA), followed by using another microfiber towel (decontamination method 2).
Methods: A simulated contaminant (Magic Fluorescent Glow Paint for Face and Body, iLC Shenzhen Fulimei Technology Co.
Behind the glow: unveiling the nature of NanoLuc reactants and products.
Phys Chem Chem Phys
November 2024
Chimie ParisTech, CNRS, Institute of Chemistry for Health and Life Sciences, PSL Research University, F-75005 Paris, France.
Due to the largely recognized utility of bioluminescence in many fields, a wide variety of luciferase-luciferin systems have been investigated in order to find the best-suited for a number of different applications. The collected knowledge has allowed the identification of a few necessary, or at least desirable, properties, such as bright luminescence, low background signal and small dimension of the enzyme that must exhibit structural stability at operating conditions. The NanoLuc-furimazine pair seems to meet all these requirements, but the mechanism of the reaction and the characteristics of the species responsible for the emission remain unknown.
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