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Replication stress causes delayed mitotic entry and chromosome 12 fragility at the ANKS1B large neuronal gene in human induced pluripotent stem cells.
Chromosome Res
August 2023
Laboratory of Mutagenesis, Research Centre for Medical Genetics, Moscow, Russia.
Substantial background level of replication stress is a feature of embryonic and induced pluripotent stem cells (iPSCs), which can predispose to numerical and structural chromosomal instability, including recurrent aberrations of chromosome 12. In differentiated cells, replication stress-sensitive genomic regions, including common fragile sites, are widely mapped through mitotic chromosome break induction by mild aphidicolin treatment, an inhibitor of replicative polymerases. IPSCs exhibit lower apoptotic threshold and higher repair capacity hindering fragile site mapping.
View Article and Find Full Text PDFTowards developing a coupled stability theory for haptic systems, we study the interaction of operators with time-delayed force feedback. In this work, we analyzed and validated experimentally the stability boundaries of an uncoupled system - without considering the human. We then designed an experiment in which the participants used a haptic device to interact with virtual elastic force fields in a stiffness discrimination task.
View Article and Find Full Text PDFStability and bifurcation analysis of a heroin model with diffusion, delay and nonlinear incidence rate.
Model Earth Syst Environ
April 2021
Department of Mathematics, National Institute of Technology Durgapur, Durgapur, 713209 India.
As we all know, the use of heroin and other drugs in Europe and more specifically in Ireland and the resulting prevalence are well documented. A huge population is still dying using heroin every day. This may happen due to, several reasons like, excessive use of painkiller, lack of awareness etc.
View Article and Find Full Text PDFDelay-induced wave instabilities in single-species reaction-diffusion systems.
Phys Rev E
November 2017
Institute of Physics, Chemnitz University of Technology, D-09107 Chemnitz, Germany.
The Turing (wave) instability is only possible in reaction-diffusion systems with more than one (two) components. Motivated by the fact that a time delay increases the dimension of a system, we investigate the presence of diffusion-driven instabilities in single-species reaction-diffusion systems with delay. The stability of arbitrary one-component systems with a single discrete delay, with distributed delay, or with a variable delay is systematically analyzed.
View Article and Find Full Text PDFAn active balance board system with real-time control of stiffness and time-delay to assess mechanisms of postural stability.
J Biomech
July 2017
School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907-2088, United States. Electronic address:
Increased time-delay in the neuromuscular system caused by neurological disorders, concussions, or advancing age is an important factor contributing to balance loss (Chagdes et al., 2013, 2016a,b). We present the design and fabrication of an active balance board system that allows for a systematic study of stiffness and time-delay induced instabilities in standing posture.
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