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Updates on Intrinsic Medicinal Chemistry of 1,4-dihydropyridines, Perspectives on Synthesis and Pharmacokinetics of Novel 1,4-dihydropyrimidines as Calcium Channel Blockers: Clinical Pharmacology.
Curr Top Med Chem
January 2025
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.
Background: Several chemical studies described the physiological efficacy of 1,4- dihydropyridines (DHPs). DHPs bind to specific sites on the α1 subunit of L-type calcium channels, where they demonstrate a more pronounced inhibition of Ca2+ influx in vascular smooth muscle compared to myocardial tissue. This selective inhibition is the basis for their preferential vasodilatory action on peripheral and coronary arteries, a characteristic that underlies their therapeutic utility in managing hypertension and angina.
View Article and Find Full Text PDFMultielectrode catheter-based pulsed electric field vs. cryoballoon for atrial fibrillation ablation: a systematic review and meta-analysis.
Europace
December 2024
Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels 1090, Belgium.
Article Synopsis
- Pulsed field ablation (PFA) is a new treatment for atrial fibrillation (AF) that shows strong safety and efficacy by specifically targeting heart muscle cells while sparing nearby tissues.
- A meta-analysis comparing PFA with cryoballoon ablation (CRYO) found that PFA had higher procedural success rates and fewer complications, along with shorter procedural and fluoroscopy times.
- However, there were no significant differences in major complications or freedom from atrial tachyarrhythmias after one year between the two techniques.
Article Synopsis
- The study aimed to identify predictors of adverse cardiovascular events following edge-to-edge transcatheter mitral valve repair (TMVR) in patients with severe mitral regurgitation (MR), focusing on heart structure and function changes over time.
- It involved 73 high surgical risk patients (average age 71) who underwent TMVR, measuring various heart metrics before, shortly after, and one year post-procedure, including myocardial function and NT-proBNP levels.
- Results showed a significant reduction in MR in both primary and secondary categories within 12 months, alongside changes in heart chamber size and improvements in certain functional metrics, despite initial impairments in left ventricular function right after surgery.
Novel agents in development for the treatment of resistant Gram-negative infections.
Expert Rev Anti Infect Ther
November 2024
Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Article Synopsis
- Several new drugs are in advanced clinical trials aimed at treating resistant Gram-negative bacteria, which are difficult to treat with current antibiotics.
- The review highlights agents that have either completed or are currently in phase-3 trials, focusing on research up to May 2024.
- The novel agents, mainly β-lactams and β-lactam/β-lactamase inhibitors, show effectiveness against certain resistant strains, but most of their efficacy has been tested against bacteria that are still susceptible, making real-world studies important for future treatment guidelines.
Utilization of the multi-theory model (MTM) of health behavior change to explain health behaviors: A systematic review.
Health Promot Perspect
July 2024
Department of Social and Behavioral Health, School of Public Health, University of Nevada, Las Vegas, NV 89119, USA.
Background: The utilization of a theoretical framework is vital in health promotion research, particularly when endeavoring to modify health behaviors. This systematic review aimed at evaluating and synthesizing evidence through studies conducted using the fourth-generation multi-theory model (MTM) of health behavior change for its effectiveness.
Methods: A comprehensive article search was performed across MEDLINE, CINAHL, and Academic Search Premier.
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