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Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM.
Proc Natl Acad Sci U S A
January 2025
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
The homo-dodecameric ring-shaped RNA binding attenuation protein (TRAP) from binds up to twelve tryptophan ligands (Trp) and becomes activated to bind a specific sequence in the 5' leader region of the operon mRNA, thereby downregulating biosynthesis of Trp. Thermodynamic measurements of Trp binding have revealed a range of cooperative behavior for different TRAP variants, even if the averaged apparent affinities for Trp have been found to be similar. Proximity between the ligand binding sites, and the ligand-coupled disorder-to-order transition has implicated nearest-neighbor interactions in cooperativity.
View Article and Find Full Text PDFData-model interactive Rul prediction of stochastic degradation devices with multiple uncertainty quantification and multi-sensor information fusion.
ISA Trans
December 2024
College of Information Engineering, Zhejiang University of Technology, Hangzhou, 310023, China.
This paper proposes an improved remaining useful life (RUL) prediction method for stochastic degradation devices monitored by multi-source sensors under data-model interactive framework. Firstly, the interrelationships among sensors are established using k-nearest neighbor (KNN), and the composite health index (CHI) is constructed by aggregating the multi-source sensor information through the graph convolutional network (GCN). Secondly, a stochastic degradation model with triple uncertainty at any initial degradation level is established to improve the matching degree between the stochastic degradation model and the actual degradation process.
View Article and Find Full Text PDFEffects of Temperature and Random Forces in Phase Transformation of Multi-Stable Systems.
Entropy (Basel)
December 2024
Department of Civil, Environmental, Land, Building Engineering and Chemistry (DICATECh), Polytechnic University of Bari, Via Orabona 4, 70125 Bari, Italy.
Multi-stable behavior at the microscopic length-scale is fundamental for phase transformation phenomena observed in many materials. These phenomena can be driven not only by external mechanical forces but are also crucially influenced by disorder and thermal fluctuations. Disorder, arising from structural defects or fluctuations in external stimuli, disrupts the homogeneity of the material and can significantly alter the system's response, often leading to the suppression of cooperativity in the phase transition.
View Article and Find Full Text PDFEmergence and characterization of attraction in a dynamic Hubbard model.
Sci Rep
December 2024
College of Engineering and Technology, American University of the Middle East, 54200, Egaila, Kuwait.
The Dynamic Hubbard Model (DHM) has been introduced as a framework for the electron-hole asymmetry observed in materials like high-temperature superconductors. In this study, we aim to understand the intricate dynamics of hole interactions, particularly focusing on the competition between on-site repulsion and hole-lattice coupling. Our results reveal a striking feature-an effective nearest-neighbor attraction between holes, even in the presence of the on-site repulsion typical of Mott insulators.
View Article and Find Full Text PDFNonuniversality of Aging during Phase Separation of the Two-Dimensional Long-Range Ising Model.
Phys Rev Lett
December 2024
Institut für Theoretische Physik, Universität Leipzig, IPF 231101, 04081 Leipzig, Germany.
We investigate the aging properties of phase-separation kinetics following quenches from T=∞ to a finite temperature below T_{c} of the paradigmatic two-dimensional conserved Ising model with power-law decaying long-range interactions ∼r^{-(2+σ)}. Physical aging with a power-law decay of the two-time autocorrelation function C(t,t_{w})∼(t/t_{w})^{-λ/z} is observed, displaying a complex dependence of the autocorrelation exponent λ on σ. A value of λ=3.
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