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Photoreceptor-RPE loss ratio and fundus autofluorescence patterns as predictive factors for lesion progression in geographic atrophy.
Acta Ophthalmol
December 2024
Department of Ophthalmology, Landesklinikum Mistelbach-Gänserndorf, Mistelbach, Austria.
Article Synopsis
- This study investigates how the ratio of photoreceptor (PR) loss to retinal pigment epithelium (RPE) loss affects the progression of geographic atrophy (GA) in patients.
- The research included 87 treatment-naïve patients with GA and analyzed their multimodal images over a follow-up period of 6 to 24 months, discovering correlations between the visual patterns and rates of GA progression.
- Results indicated that higher PR-RPE loss ratios are associated with faster GA growth and specific abnormal fundus autofluorescence (FAF) patterns, providing insights for predicting disease progression based on imaging characteristics.
Foveal avascular zone enlargement correlates with visual acuity decline in patients with diabetic retinopathy.
Ophthalmol Retina
December 2024
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:
Purpose: The foveal avascular zone (FAZ) area has been explored as a measure of macular ischemia in diabetic retinopathy (DR) but is limited by its wide variability even in healthy individuals. We hypothesized that FAZ enlargement, which we defined as the difference between the functional FAZ (on optical coherence tomography angiography; OCTA) and structural FAZ (en face OCT), may be a more accurate metric of macular ischemia. In this study, we test the hypothesis that FAZ enlargement is associated with decreased best-corrected visual acuity (BCVA) and low luminance visual acuity (LLVA) and performs better than the functional FAZ as a marker of vision loss.
View Article and Find Full Text PDFVerteporfin combined with ROCK inhibitor promotes the restoration of corneal endothelial cell dysfunction in rats.
Biochem Pharmacol
January 2025
Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China; Key Lab of Visual Damage and Regeneration, Chongqing, 401329, PR China. Electronic address:
Article Synopsis
- * VP is shown to reverse endothelial-to-mesenchymal transition (EndMT) and helps improve corneal hydration but surprisingly inhibits cell proliferation.
- * The optimal combination of VP with ROCK inhibitors at a 1:1 ratio enhances cell function and adhesion while promoting corneal repair, offering a promising new treatment strategy for corneal endothelial damage.
Do smaller P300 amplitudes in schizophrenia result from larger variability in temporal processing?
Schizophrenia (Heidelb)
November 2024
Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Freiburg, Germany.
The P3b is a prominent event-related potential (ERP) with maximal amplitude between 250 ms and 500 ms after the onset of a rare target stimulus within a sequence of standard non-target stimuli (oddball paradigm). Several studies found reduced P3b amplitudes in patients with schizophrenia compared to neurotypicals. Our work and the literature suggest that temporal imprecision may play a large pathophysiological role in schizophrenia.
View Article and Find Full Text PDFNovel Bulk Quantum Hall Effect in Nanostructured TaP Macroscopic Crystals.
Nano Lett
November 2024
National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, China.
Article Synopsis
- The study reports the observation of bulk quantum Hall effect (QHE) in large TaP crystals, which is a significant advancement compared to previous findings in smaller 2D systems.
- This phenomenon is characterized by simultaneous quantum plateaus in both transverse and vertical resistivity, indicating coherent electron transport.
- The observed bulk QHE occurs due to the interaction of Landau cyclotron movement in a magnetic field and the periodic structure of nanometer-scale lamellae, suggesting that engineering microstructures can enhance electron transport in bulk materials.
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