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Revealing an origin of temperature-dependent structural change in intrinsically disordered protein.
Biophys J
December 2024
Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Sennan-gun, Osaka 590-0494 Japan. Electronic address:
Intrinsically disordered proteins (IDPs) show structural changes stimulated by changes in external conditions. This study aims to reveal the temperature dependence of the structure and dynamics of the intrinsically disordered region of Hef, one of the typical IDPs, using an integrative approach. Small-angle X-ray scattering (SAXS) and circular dichroism (CD) studies revealed that the radius of gyration and ellipticity at 222 nm remained constant up to 313-323 K, followed by a decline above this temperature range.
View Article and Find Full Text PDFContinuity of Short-Time Dynamics Crossing the Liquid-Liquid Phase Separation in Charge-Tuned Protein Solutions.
J Phys Chem Lett
December 2024
Institut Max von Laue-Paul Langevin, 71 Av. des Martyrs, 38042 Grenoble, France.
Liquid-liquid phase separation (LLPS) constitutes a crucial phenomenon in biological self-organization, not only intervening in the formation of membraneless organelles but also triggering pathological protein aggregation, which is a hallmark in neurodegenerative diseases. Employing incoherent quasi-elastic neutron spectroscopy (QENS), we examine the short-time self-diffusion of a model protein undergoing LLPS as a function of phase splitting and temperature to access information on the nanosecond hydrodynamic response to the cluster formation both within and outside the LLPS regime. We investigate the samples as they dissociate into microdroplets of a dense protein phase dispersed in a dilute phase as well as the separated dense and dilute phases obtained from centrifugation.
View Article and Find Full Text PDFFerroelectric, Switchable Dielectric and Nonlinear Optical Properties in Inorganic-Organic Lead-Free 1D Hybrids Based on Bi(III) and Azetidine: (CNH)[BiCl], (CNH)[BiBr].
J Phys Chem Lett
November 2024
Faculty of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383 Wrocław, Poland.
This study investigates lead-free organic-inorganic hybrids (CNH)[BiCl] () and (CNH)[BiBr] (), focusing on their structural, dielectric, ferroelectric, and optical properties. Both compounds exhibit paraelectric () to ferroelectric () phase transitions (PTs) at 230/233 K and 228/229 K, respectively, transitioning from orthorhombic () to monoclinic (2) phases, with distorted [BiX] octahedra forming 1D chains. Quasielastic neutron scattering and solid-state H NMR studies reveal the localized motion of azetidinium cations.
View Article and Find Full Text PDFEmergent Research Trends on the Structural Relaxation Dynamics of Molecular Clusters: From Structure-Property Relationship to New Function Prediction.
Acc Chem Res
October 2024
State Key Laboratory of Luminescent Materials and Devices & South China Advanced Institute for Soft Matter Science and Technology, Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials, South China University of Technology, Guangzhou 510640, P. R. China.
Article Synopsis
- - Molecular clusters (MCs) are precisely organized collections of atoms that can be customized for specific purposes and used to create advanced materials with layered structures and enhanced functions.
- - Unlike traditional polymers, MCs exhibit unique viscoelastic properties, maintaining elasticity even at higher temperatures, and offer new avenues for designing soft materials without the linked chain designs found in polymers.
- - Research into the structural relaxation dynamics of MCs, aided by improved measurement techniques, allows scientists to understand and quantify the movement of different structural units, paving the way for innovative material development and overcoming challenges faced by conventional materials.
Dynamics of Polyalkylfluorene Conjugated Polymers: Insights from Neutron Spectroscopy and Molecular Dynamics Simulations.
J Phys Chem B
June 2024
Department of Physics, Imperial College London, Prince Consort Road, London SW7 2AZ, U.K.
The dynamics of the conjugated polymers poly(9,9-dioctylfluorene) (PF8) and poly(9,9-didodecylfluorene) (PF12), differing by the length of their side chains, is investigated in the amorphous phase using the temperature-dependent quasielastic neutron scattering (QENS) technique. The neutron spectroscopy measurements are synergistically underpinned by molecular dynamics (MD) simulations. The probe is focused on the picosecond time scale, where the structural dynamics of both PF8 and PF12 would mainly be dominated by the motions of their side chains.
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