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Floquet-Driven Crossover from Density-Assisted Tunneling to Enhanced Pair Tunneling.
Phys Rev Lett
December 2024
Physikalisches Institut, University of Bonn, 53115 Bonn, Germany.
We investigate the experimental control of pair tunneling in a double-well potential using Floquet engineering. We demonstrate a crossover from a regime with density-assisted tunneling to dominant pair tunneling by tuning the effective interactions. Furthermore, we show that the pair tunneling rate can be enhanced not only compared to the Floquet-reduced single-particle tunneling but even beyond the static superexchange rate, while keeping the effective interaction in a relevant range.
View Article and Find Full Text PDFConformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.
Sci Rep
January 2025
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
α-Klotho (KLA) is a type-1 membranous protein that can associate with fibroblast growth factor receptor (FGFR) to form co-receptor for FGF23. The ectodomain of unassociated KLA is shed as soluble KLA (sKLA) to exert FGFR/FGF23-independent pleiotropic functions. The previously determined X-ray crystal structure of the extracellular region of sKLA in complex with FGF23 and FGFR1c suggests that sKLA functions solely as an on-demand coreceptor for FGF23.
View Article and Find Full Text PDFDimensional confinement and superdiffusive rotational motion of uniaxial colloids in the presence of cylindrical obstacles.
J Chem Phys
January 2025
Out of Equilibrium Group, Department of Physics, Indian Institute of Technology Delhi, New Delhi 110016, India.
In biological systems such as cells, the macromolecules, which are anisotropic particles, diffuse in a crowded medium. In the present work, we have studied the diffusion of spheroidal particles diffusing between cylindrical obstacles by varying the density of the obstacles as well as the spheroidal particles. Analytical calculation of the free energy showed that the orientational vector of a single oblate particle will be aligned perpendicular, and a prolate particle will be aligned parallel to the symmetry axis of the cylindrical obstacles in equilibrium.
View Article and Find Full Text PDFResistive-Pulse Sensing Coupled with Fluorescence Lifetime Imaging Microscopy for Differentiation of Individual Liposomes.
ACS Nano
January 2025
Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, United States.
Characterization of individual biological nanoparticles can be significantly improved by coupling complementary analytical methods. Here, we combine resistive-pulse sensing (RPS) with fluorescence lifetime imaging microscopy (FLIM) to differentiate liposomes at the single-particle level. RPS measures the particle volume, shape, and surface-charge density, and FLIM determines the fluorescence lifetime of the fluorophore associated with the lipid membrane.
View Article and Find Full Text PDFLoading of Extracellular Vesicles with Nucleic Acids via Hybridization with Non-Lamellar Liquid Crystalline Lipid Nanoparticles.
Adv Sci (Weinh)
December 2024
Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, 8093, Switzerland.
The translation of cell-derived extracellular vesicles (EVs) into biogenic gene delivery systems is limited by relatively inefficient loading strategies. In this work, the loading of various nucleic acids into small EVs via their spontaneous hybridization with preloaded non-lamellar liquid crystalline lipid nanoparticles (LCNPs), forming hybrid EVs (HEVs) is described. It is demonstrated that LCNPs undergo pH-dependent structural transitions from inverse hexagonal (H) phases at pH 5 to more disordered non-lamellar phases, possibly inverse micellar (L) or sponge (L) phases, at pH 7.
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