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Biologics in allergology and clinical immunology: Update on therapies for atopic diseases, urticaria, and angioedema and on safety aspects focusing on hypersensitivity reactions.
Allergol Select
November 2024
Institute of Allergology, Charité Universitätsmedizin Berlin und Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin.
Article Synopsis
- Targeted therapies using biologics for atopic diseases, urticaria, and angioedema are advancing quickly, with several new antibodies developed, tested, and approved for clinical use, like omalizumab and dupilumab.
- There is ongoing research into combining different biologics for enhanced treatment efficacy, expanding their applications to conditions like food allergies and eosinophilic esophagitis.
- There are emerging concerns about unexpected side effects and hypersensitivity reactions associated with these therapies, raising important questions about their safety and mechanisms, particularly in specific patient groups like children.
A neural network potential energy surface of the Li system and quantum dynamics studies for the Li + Li → LiLi + Li reaction.
Phys Chem Chem Phys
June 2024
Department of Physics, Liaoning University, Shenyang 110036, China.
A high-precision global potential energy surface (PES) of the Li system is constructed based on high-level calculations, and the root-mean-square error is 5.54 cm. The short-range of the PES is fitted by the fundamental invariant neural network (FI-NN) method, while the long-range uses a function with an accurate asymptotic potential energy form, and the two regions are connected by a switching function.
View Article and Find Full Text PDFYield estimation of radionuclides from Li-induced reactions: A comparative analysis for Ru.
Appl Radiat Isot
June 2024
Department of Physics, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India. Electronic address:
The article reports the production yields of the medically relevant Ru radionuclides and other co-produced radionuclides from Li-induced reactions on Nb target within the 20-45 MeV energy range. The residues were measured employing the activation technique followed by the offline γ-spectroscopy. Statistical model calculations using EMPIRE3.
View Article and Find Full Text PDFFeatures of Helium and Tritium Release from LiTiO Ceramic Pebbles under Neutron Irradiation.
Materials (Basel)
August 2023
Satbayev University, 22 Satbayev str., Almaty 050013, Kazakhstan.
The operation of fusion reactors is based on the reaction that occurs when two heavy hydrogen isotopes, deuterium and tritium, combine to form helium and a neutron with an energy of 14.1 MeV D + T → He + n. For this reaction to occur, it is necessary to produce tritium in the facility itself, as tritium is not common in nature.
View Article and Find Full Text PDFYield of residues produced in Li reaction on Ta: A comparative analysis for Os.
Appl Radiat Isot
October 2023
Department of Physics, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India. Electronic address:
The present work reports an analysis of the production yield of residues from the Li ＋ Ta reaction in a low-energy regime. The experimental yield of Os, Os, Os, Re, Ta, Ta, and Ta have been measured in the 27-43 MeV energy window and compared with equilibrium and pre-equilibrium model calculations under the framework of the nuclear reaction model code, EMPIRE-3.2.
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