Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1103/physrevc.37.328 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Histone N-tails modulate sequence-specific positioning of nucleosomes.
J Biol Chem
December 2024
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:
Spatial organization of chromatin is essential for cellular functioning. However, the precise mechanisms governing sequence-dependent positioning of nucleosomes on DNA still remain unknown in detail. Existing algorithms, taking into account the sequence-dependent deformability of DNA and its interactions with the histone globular domains, predict rotational setting of only 65% of human nucleosomes mapped in vivo.
View Article and Find Full Text PDFHindlimb locomotor biomechanics of the derived therizinosaur Nothronychus: Functional changes in the line to birds and convergence with large-bodied neornitheans.
Anat Rec (Hoboken)
December 2024
Biology Department, Northland Pioneer College, Holbrook, Arizona, USA.
Nothronychus graffami was a large therizinosaur represented by a single well-preserved individual from the Turonian Tropic Shale of southern Utah. It is characterized by an enlarged abdomen, small tail, and an extensively pneumatized axial skeleton, and is frequently regarded as herbivorous. Given the overall tail reduction and the development of a wide fused synsacrum with widely spaced acetabulae, it is reconstructed with an anteriorly rotated femur and a displaced resting ground reaction force anterior to the center of mass.
View Article and Find Full Text PDFStructural Design and Kinematic Modeling of Highly Biomimetic Flapping-Wing Aircraft with Perching Functionality.
Biomimetics (Basel)
December 2024
School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Birds use their claws to perch on branches, which helps them to recover energy and observe their surroundings; however, most biomimetic flapping-wing aircraft can only fly, not perch. This study was conducted on the basis of bionic principles to replicate birds' claw and wing movements in order to design a highly biomimetic flapping-wing aircraft capable of perching. First, a posture conversion module with a multi-motor hemispherical gear structure allows the aircraft to flap, twist, swing, and transition between its folded and unfolded states.
View Article and Find Full Text PDFA small molecule enhances arrestin-3 binding to the β-adrenergic receptor.
bioRxiv
December 2024
Istanbul Medipol University, School of Engineering and Natural Sciences, Department of Biomedical Engineering, 34810, Istanbul, Turkey.
G protein-coupled receptor (GPCR) signaling is terminated by arrestin binding to a phosphorylated receptor. Binding propensity has been shown to be modulated by stabilizing the pre-activated state of arrestin through point mutations or C-tail truncation. Here, we hypothesize that pre-activated rotated states can be stabilized by small molecules, and this can promote binding to phosphorylation-deficient receptors, which underly a variety of human disorders.
View Article and Find Full Text PDFMiR-495 reverses in the mechanical unloading, random rotating and aging induced muscle atrophy via targeting MyoD and inactivating the Myostatin/TGF-β/Smad3 axis.
Arch Biochem Biophys
December 2024
Institute for Special Environmental Biophysics, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, Shaanxi, China. Electronic address:
Mechanical unloading can lead to homeostasis imbalance and severe muscle disease, in which muscle atrophy was one of the disused diseases. However, there were limited therapeutic targets for such diseases. In this study, miR-495 was found dramatically reduced in atrophic skeletal muscle induced by mechanical unloading models both in vitro and in vivo, including the random positioning model (RPM), tail-suspension (TS) model, and aged mice model.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!