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High-density multielectrode arrays bring cellular resolution to neuronal activity and network analyses of corticospinal motor neurons.
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Department of Neurology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave, Chicago, IL, 60611, USA.
Corticospinal motor neurons (CSMN), located in the motor cortex of the brain, are one of the key components of the motor neuron circuitry. They are in part responsible for the initiation and modulation of voluntary movement, and their degeneration is the hallmark for numerous diseases, such as amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia, and primary lateral sclerosis. Cortical hyperexcitation followed by in-excitability suggests the early involvement of cortical dysfunction in ALS pathology.
View Article and Find Full Text PDFEffects of transcranial magnetic stimulation combined with extracorporeal shockwave therapy for poststroke spasticity: study protocol for a randomised controlled trial.
BMJ Open
January 2025
Department of Rehabilitation, Daping Hospital, Army Medical University, Chongqing, China
Introduction: Spasticity is a common complication of stroke, which is related to poor motor recovery and limitations in the performance of activities. Both transcranial magnetic stimulation (TMS) and extracorporeal shockwave therapy (ESWT) are effective treatment methods for poststroke spasticity (PSS). However, there is no existing study exploring the safety and effectiveness of TMS combined with ESWT for PSS.
View Article and Find Full Text PDFThe effects of diazepam on sleep depend on the photoperiod.
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Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University, Medical Centre, Leiden, 2333, ZC, The Netherlands.
Daylength (i.e., photoperiod) provides essential information for seasonal adaptations of organisms.
View Article and Find Full Text PDFTime-resolved fluorescence measurements of dissolved organic matter (DOM) as a function of environmental parameters in estuarine waters.
Environ Sci Pollut Res Int
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Department of Chemistry, College of Science and Engineering, Western Washington University, 516 High Street, Bellingham, WA, 98229, USA.
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View Article and Find Full Text PDFFXR1 Deletion from Cortical Parvalbumin Interneurons Modifies their Excitatory Synaptic Responses.
eNeuro
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Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, 53705
Fragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1 family, has been linked to psychiatric disorders including autism and schizophrenia. Parvalbumin (PV) interneurons play critical roles in cortical processing, and have been implicated in FXR1-linked mental illnesses. Targeted deletion of FXR1 from PV interneurons in mice has been shown to alter cortical excitability and elicit schizophrenia-like behavior.
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