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Numeric uptake drives nanoplastic toxicity: Size-effects uncovered by toxicokinetic-toxicodynamic (TKTD) modeling.
J Hazard Mater
January 2025
Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, State Key Laboratory of Marine Environmental Science, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem, College of the Environment and Ecology, Xiamen University, Xiamen 361102, China. Electronic address:
Predicting nanoplastic bioaccumulation and toxicity using process-based models is challenging due to the difficulties in tracing them at low concentrations. This study investigates the size-dependent effects of nanoplastic exposure on Daphnia magna using a toxicokinetic-toxicodynamic (TKTD) model. Palladium-doped fluorescent nanoplastics in three sizes (30-nm, 66-nm, 170-nm) were tested at two numeric exposure concentrations.
View Article and Find Full Text PDFBackground: Biomarkers, such as blood p-tau181, p-tau217, and p-tau231, have been created and verified to mirror the pathophysiology of tau and amyloid-β (Aβ) in the brain . Sleep spindles are known to contribute to memory consolidation and generalization and may therefore be a promising biomarker in preclinical Alzheimer's Disease (AD) . The present study investigated the relationship between sleep spindles and p-tau levels in cognitively healthy older African Americans.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Washington University in St. Louis, Saint Louis, MO, USA.
Background: Alzheimer disease (AD) is a chronic progressive neurodegenerative disorder that presents with cognitive dysfunction, memory loss, language difficulties, emotion dysregulation, and the eventual loss of motor function and death. Magnetic resonance imaging (MRI) shows early atrophy in the medial temporal lobes, which then spreads to the posterior temporal lobe, parietal lobe, and finally the frontal lobe with relative sparing of the sensorimotor cortex. Social disadvantage has been shown to have potentially additive impacts on aging trajectories.
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Alzheimers Dement
December 2024
Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, GIP Cyceron, Caen, France.
White matter hyperintensities (WMH) are highly prevalent in aging and Alzheimer's disease (AD) and typically attributed to vascular damage and cerebral small vessel disease. Yet, several lines of evidence from the literature emphasize the heterogeneity in the mechanisms leading to WMH, notably in AD, suggesting that WMH may be partly attributable to AD. Thus, firstly, neuropathological studies demonstrate heterogeneity in WMH histology, with indications of a link between tau pathology, Wallerian degeneration, and WMH severity.
View Article and Find Full Text PDFBackground: The prevalence of dementia in Peru's northern regions is poorly documented, largely due to the scarcity of studies employing validated assessment tools for the elderly. Notably, this area is marked by pronounced disparities, encompassing a wide range of socioeconomic statuses and predominantly low educational attainment. The confluence of risk factors, including educational and socioeconomic deprivation, prevalent diseases, suboptimal health conditions, chronic stress, and lifelong malnutrition, poses a significant risk of escalating dementia cases over the next two decades.
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