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Development and Characterization of Novel Combinations and Compositions of Nanostructured Lipid Carrier Formulations Loaded with Trans-Resveratrol for Pulmonary Drug Delivery.
Pharmaceutics
December 2024
Department of Pharmaceutical Sciences, College of Pharmacy, QU Health Sector, Qatar University, Doha 2713, Qatar.
Background/objectives: This study aimed to fabricate, optimize, and characterize nanostructured lipid carriers (NLCs) loaded with trans-resveratrol (TRES) as an anti-cancer drug for pulmonary drug delivery using medical nebulizers.
Methods: Novel TRES-NLC formulations (F1-F24) were prepared via hot, high-pressure homogenization. One solid lipid (Dynasan 116) was combined with four liquid lipids (Capryol 90, Lauroglycol 90, Miglyol 810, and Tributyrin) in three different ratios (10:90, 50:50, and 90:10 /), with a surfactant (Tween 80) in two different concentrations (0.
Green Sol-Gel Synthesis of Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications.
Pharmaceutics
December 2024
i3N and Department of Physics, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
Background/objectives: The unique properties of iron oxide nanoparticles have attracted significant interest within the biomedical community, particularly for magnetic hyperthermia applications. Various synthesis methods have been developed to optimize these nanoparticles.
Methods: In this study, we employed a powdered coconut water (PCW)-assisted sol-gel method to produce magnetite nanoparticles for the first time.
Usefulness of Size-Exclusion Chromatography-Multi-Angle Light Scattering to Assess Particle Composition and Protein Impurities for Quality Control of Therapeutic Exosome Preparations.
Pharmaceutics
November 2024
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Kanagawa, Japan.
Extracellular vesicles (EVs), including exosomes, are promising pharmaceutical modalities. They are purified from cell culture supernatant; however, the preparation may contain EVs with the desired therapeutic effects and different types of EVs, lipoproteins, and soluble proteins. Evaluating the composition of particulate impurities and the levels of protein impurities in final preparations is critical for quality control.
View Article and Find Full Text PDFDevelopment and Characterization of Spray-Dried Combined Levofloxacin-Ambroxol Dry Powder Inhaler Formulation.
Pharmaceutics
November 2024
Pharmacy Discipline, School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4000, Australia.
This study explores the development and characterization of spray-dried composite microparticles consisting of levofloxacin (LVX, a broad-spectrum antibiotic), and ambroxol (AMB, a mucolytic agent that has antibacterial and antibiofilm properties), for the intended application of the drug against lower respiratory tract infections (LRTIs). A range of LVX to AMB mass ratios (1:1, 1:0.5, and 1:0.
View Article and Find Full Text PDFFabrication of Polytetrafluoroethylene-Reinforced Fluorocarbon Composite Coatings and Tribological Properties Under Multi-Environment Working Conditions.
Polymers (Basel)
December 2024
School of Mechanical and Electrical Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, China.
Currently, few studies have been conducted on the use of fluorocarbon resin (FEVE) and polytetrafluoroethylene (PTFE) as adhesive substrates and lubricating and anti-corrosion fillers, respectively, for the fabrication of PTFE-reinforced fluorocarbon composite coatings. In this paper, the tribological properties of polytetrafluoroethylene-reinforced fluorocarbon composite coatings were investigated through orthogonal tests under various operating conditions. The optimal configuration for coating preparation under dry friction and aqueous lubrication was thus obtained: the optimal filler particle size, mass ratio of FEVE to PTFE, spraying pressure, and curing agent content were 50 μm, 3:4.
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