AI Article Synopsis
- Repeated exposure to HIV doesn't always lead to seroconversion, highlighting a need for understanding protective factors against HIV progression for vaccine development.
- Nineteen at-risk individuals were tested for HIV immunity, revealing that none had the protective Delta32CCR-5 genotype, but 41.1% of exposed uninfected subjects showed HIV-specific cytotoxic T lymphocytes (CTL).
- The study found that CTL could recognize the virus and remain active for up to 34 months after exposure, suggesting that some individuals can develop immunity to HIV without becoming infected or showing disease symptoms.
Article Abstract
Repeated exposure to human immunodeficiency virus (HIV) does not always result in seroconversion. Understanding the conditions that permit or protect against progressive infection with HIV is important for vaccine development. Nineteen subjects at risk for HIV infection were CCR-5 genotyped and screened for virus-specific memory cytotoxic T lymphocytes (CTL). None had the Delta32CCR-5/Delta32CCR-5 genotype associated with HIV resistance. HIV-specific CTL were detected in 7 (41.1%) of 17 exposed uninfected subjects versus 0 of 14 seronegative subjects with no HIV risk factors (P=.006, chi2 test). Recognition of virus by CTL in exposed uninfected subjects was major histocompatibility complex class I-restricted and multispecific, and specificity could change with time. Activity could persist up to 34 months after the last virus exposure. The presence of HIV-specific CTL in a greater proportion of seronegative HIV-exposed versus unexposed subjects supports the notion that in some cases, virus exposure induces HIV immunity without seroconversion or disease progression.
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| http://dx.doi.org/10.1086/314621 | DOI Listing |
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