The development of glaucoma involves changes in the chamber humor caused by hydrodynamic disorders. Primary glaucoma is often combined with lens opacities. Comparison of the content of protein and protein fractions in aqueous humor and blood serum of patients with glaucoma and different degree of lens opacity showed that, in contrast to senile cataract, cataract in a glaucomatous eye forms when the permeability of the blood-eye barrier is increased, which justifies the administration of drugs stabilizing it.
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Drug Des Devel Ther
August 2024
Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.
Mol Cell Biochem
June 2024
Department of Health Services, Logistics University of People's Armed Police Force, Tianjin, Chenlin Road, Hedong District, Tianjin, 300162, China.
Posterior ocular disease, a disease that accounts for 55% of all ocular diseases, can contribute to permanent vision loss if left without treatment. Due to the special structure of the eye, various obstacles make it difficult for drugs to reach lesions in the posterior ocular segment. Therefore, the development of highly permeable targeted drugs and delivery systems is particularly important.
View Article and Find Full Text PDFEur J Med Chem
September 2023
Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:
Angiogenesis is the biological process in which existing blood vessels generate new ones and it is essential for body growth and development, wound healing, and granulation tissue formation. Vascular endothelial growth factor receptor (VEGFR) is a crucial cell membrane receptor that binds to VEGF to regulate angiogenesis and maintenance. Dysregulation of VEGFR signaling can lead to several diseases, such as cancer and ocular neovascular disease, making it a crucial research area for disease treatment.
View Article and Find Full Text PDFBMC Ophthalmol
April 2023
Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, People's Republic of China.
Background: The destruction of blood eye barrier and the administration of corticosteroid eyedrops after phacoemulsification surgery can lead to the replication of the local potential pathogens. With the rapid increase and popularization of cataract surgery, all kinds of rare postoperative complications have appeared. Here, we report a case of interstitial keratitis and secondary glaucoma after cataract surgery, which may be related to late congenital syphilis, which eventually led to blindness in the right eye.
View Article and Find Full Text PDFOcul Immunol Inflamm
September 2023
Prof Brien Holden Eye Research Center, LV Prasad Eye Institute, Hyderabad, India.
Purpose: To describe the pathogenesis and the general immune mechanisms of the most frequent causes of bacterial uveitis.
Methodology: Narrative review.
Results: Both extra- and intracellular bacteria can induce uveitis, whereas intracellular bacteria are generally transported into the inner eye via cells of the innate immune system, mainly macrophages.
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