[Premedication with intranasal midazolam in children of various ages].

Minerva Anestesiol

Servizio II di Anestesia e Rianimazione, Azienda Ospedaliera Arcispedale S. Anna, Ferrara.

Published: November 1998

Background And Aim: To evaluate the efficacy of premedication with midazolam (mdz) administered using a nasal route compared to diazepam (dz) administered by mouth in children of different ages.

Experimental Design: A comparative type study was performed in randomly selected pediatric patients undergoing surgery. The study lasted 3 months.

Setting: Recovery room and operating theatre for Pediatric Surgery and ENT.

Patients: A total of 248 patients were studied, divided into 3 age groups: group A were aged under 2 years; group B were pre-school age and group C were school-age.

Operations: Two subgroups were formed based on the premedication used: group M = 0.2 mg/kg of mdz using a nasal route on arrival in the operating unit; group D = 0.2 mg/kg of dz per os 45' before induction. PARAMETERS STUDIED: In addition to acceptance of treatment, which was deemed to be good, poor or refused, the authors evaluated the level of sedation (score from 5 to 1: awake-asleep), anxiety on entering SO (score from 1 to 4: none-excessive) and the level of collaboration during the induction of general anesthesia (score 1-4: excellent-nil).

Results: The nasal route was well accepted by 59% of patients in group A, 62% of group B and 97% of group C. Statistical analysis using Kruskall Wallis test showed significant differences in groups A and B between the two subgroups M and D for all the parameters studied, whereas there were no significant differences in group C.

Conclusions: Premedication with mdz using a nasal route was safe and efficacious, above all in early and later infancy.

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