[Comparative analysis of general and local immunoreactivity in patients with chronic vulvovaginitis of mixed etiology].

The clinical and pathogenetic importance of local immunity in patients with chronic vulvovaginitis (CVV) caused by fungi of the genus Candida or by mixed microflora was studied. 73 patients were examined during the period of exacerbation and 11 patients, at the phase of the remission of the disease. The levels of interferon, interleukin 1 beta, interleukin 8 and tumor necrosis factor alpha in vaginal washings (VW) were determined for the evaluation of local reactiveness and the subpopulation composition of peripheral blood lymphocytes was established. Patients with CVV in the phases of exacerbation and remission were found to have essential differences in the content of cytokines in VW, while the results obtained in the groups of patients at the stage of remission and control subjects were found to be highly similar.