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Pulsed Ultrasound-Mediated Drug Delivery Enhancement Through Human Sclera.
Transl Vis Sci Technol
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Purpose: The purpose of this study was to characterize whether pulsed ultrasound (PUS) affects transscleral drug delivery.
Methods: Fluorescein sodium (NaF, 376 Da) and fluorescein isothiocyanate-conjugated dextran 40 (FD-40, 40 kDa) were used as model drugs. Human sclera grafts were placed in modified Franz diffusion cells and were treated by PUS (1 megahertz [MHz], 0.
High correlated color temperature white light-emitting diodes disrupt refractive development in guinea pigs.
Heliyon
November 2024
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, China.
Ubiquitous white light-emitting diodes (LEDs) possess optical properties that differ from those of natural light. This difference can impact visual perception and biological functions, thus potentially affecting eye health. Myopia, which leads to visual impairments and potentially irreversible vision loss or blindness, is the most prevalent refractive error worldwide.
View Article and Find Full Text PDFEffects of Different Light Environments with Varying Spectral Composition on the Axial Lengths and Scleral Specificity Protein 1 and Collagen Type I Expression in Juvenile Guinea Pigs.
Folia Biol (Praha)
December 2024
Department of Ophthalmology, Clinical College of Yizheng People's Hospital, Jiangsu Health Vocational College, Yangzhou, Jiangsu, China.
The study aimed to investigate changes in the eye axial length in juvenile guinea pigs and the expression of scleral specificity protein 1 (Sp1) and collagen type I (Col-I) under different light environments with varying spectral composition. The animals were randomly divided into five groups: natural light (N), LED light with a low colour temperature (L), E light (E), Fulia light (F), and Gulia light (G). Axial lengths were measured every two weeks, and the expression of Sp1 and Col-I in the sclera was assessed by immunohistochemistry, Western blot and RT-qPCR.
View Article and Find Full Text PDFTensile properties of glaucomatous human sclera, optic nerve, and optic nerve sheath.
Biomech Model Mechanobiol
December 2024
Department of Ophthalmology and Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095-7002, USA.
We characterized the tensile behavior of sclera, optic nerve (ON), and ON sheath in eyes from donors with glaucoma, for comparison with published data without glaucoma. Twelve freshly harvested eyes were obtained from donors with history of glaucoma, of average age 86 ± 7 (standard deviation) years. Rectangular samples were taken from anterior, equatorial, posterior, and peripapillary sclera, and ON sheath, while ON was in native form and measured using calipers.
View Article and Find Full Text PDFEffects of artificial light with different spectral compositions on refractive development and matrix metalloproteinase 2 and tissue inhibitor of metalloproteinases 2 expression in the sclerae of juvenile guinea pigs.
Eur J Histochem
June 2024
Department of Ophthalmology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu; The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu.
Artificial light can affect eyeball development and increase myopia rate. Matrix metalloproteinase 2 (MMP-2) degrades the extracellular matrix, and induces its remodeling, while tissue inhibitor of matrix MMP-2 (TIMP-2) inhibits active MMP-2. The present study aimed to look into how refractive development and the expression of MMP-2 and TIMP-2 in the guinea pigs' remodeled sclerae are affected by artificial light with varying spectral compositions.
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