In 13 eyes tonometry was performed during trabeculotomy at the beginning, after preparation of the outer scleral lamella and after the excision of the outer wall of the canal of Schlemm. In 4 eyes this was combined with tonography. There was no significant change of the averaged i.o. pressure and the resistance to aqueous outflow. Thus in primary open angle glaucoma the resistance to aqueous outflow must be located primarily in the trabecular meshwork.
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Pharmaceutics
November 2024
Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, No. 280 University Town Outer Ring East Road, Guangzhou 510006, China.
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Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Ministry of Education, Shihezi University School of Medicine, Shihezi 832003, China.
The Chansu injection (CSI), a sterile aqueous solution derived from Chansu, is applied in clinical settings to support antitumor and anti-radiation treatments. CSI's principal active components, bufadienolides (≥90%), demonstrate potential effects on pancreatic cancer (PDAC), but their underlying mechanisms remain unclear. This study aimed to elucidate the antitumor effects and pathways associated with CSI in PDAC.
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Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia.
As the resistance of to the existing antimalarials increases, there is a crucial need to expand the antimalarial drug pipeline. We recently identified potent antimalarial compounds, namely harmiquins, hybrids derived from the β-carboline alkaloid harmine and 4-amino-7-chloroquinoline, a key structural motif of chloroquine (CQ). To further explore the structure-activity relationship, we synthesised 13 novel hybrid compounds at the position -9 of the β-carboline ring and evaluated their efficacy in vitro against 3D7 and Dd2 strains (CQ sensitive and multi-drug resistant, respectively).
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Department of Mechanical and Power Engineering, Koszalin University of Technology, Raclawicka Street 15-17, 75-620 Koszalin, Poland.
An ice slurry or an emulsion of a phase change material (PCM) is a multiphase working fluid from the so-called Latent Functional Thermal Fluid (LFTF) group. LFTF is a fluid that uses, in addition to specific heat, the specific enthalpy of the phase change of its components to transfer heat. Another fluid type has joined the LFTF group: a slurry of encapsulated phase change material (PCM).
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Department of Ophthalmology, University Medical Centre Ljubljana, Grablovičeva 46, 1000 Ljubljana, Slovenia.
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