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Cryo-EM of human rhinovirus reveals capsid-RNA duplex interactions that provide insights into virus assembly and genome uncoating.
Commun Biol
November 2024
Department of Structure of Macromolecules, Centro Nacional de Biotecnología (CNB-CSIC), Campus de Cantoblanco, Madrid, Spain.
Article Synopsis
- - The study determined the cryo-EM structure of human rhinovirus B14, revealing that 13-bp RNA duplexes are symmetrically bound around the virus's icosahedral capsid, making up about 12% of its ssRNA genome.
- - These RNA duplexes create a quasi-dodecahedral cage inside the capsid, interacting with the inner wall through non-covalent forces, particularly with basic amino acids nearby.
- - Comparing RNA-filled virions to empty capsids showed significant conformational changes in specific residues upon RNA release, suggesting mechanisms involved in rhinovirus assembly and uncoating, which could inform new antiviral strategies.
Characterization and genomic analysis phage PmP19, a novel Proteus mirabilis phage with a broad host range.
Arch Virol
October 2024
Qinghai Academy of Animal Sciences and Veterinary Medicine, Qinghai University, Xining, 810016, PR China.
A lytic Proteus mirabilis phage, PmP19, was isolated from sewage on a farm. PmP19 has an icosahedral head (60 ± 3 nm in diameter) and a short tail (15 ± 2 nm long). Its genome, a linear, double-stranded DNA molecule 44,305 bp in length with an average GC content of 51.
View Article and Find Full Text PDFCharacterization and Genomic Analyses of dsDNA Vibriophage vB_VpaM_XM1, Representing a New Viral Family.
Mar Drugs
September 2024
College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.
Article Synopsis
- A new vibriophage named vB_VpaM_XM1 (XM1) was characterized, featuring an oblate icosahedral head and a long contractile tail, with a genome of 46,056 bp and 69 open reading frames.
- * XM1 specifically lyses a limited number of bacterial strains, demonstrating a 20-minute latent period and a burst size of 398 plaque-forming units per infected cell.
- * The phage shows remarkable stability across different pH levels, temperatures, and salinity, suggesting potential for therapeutic use against certain bacterial infections.*
The Structure of : Exploring the Capsid Diversity of the .
Viruses
July 2024
Department of Biochemistry and Molecular Biology, College of Medicine, Center for Structural Biology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
(SpV4) is a bacteriophage of the , which packages circular ssDNA within non-enveloped T = 1 icosahedral capsids. It infects spiroplasmas, which are known pathogens of honeybees. Here, the structure of the SpV4 virion is determined using cryo-electron microscopy to a resolution of 2.
View Article and Find Full Text PDFModulated Cell Internalization Behavior of Icosahedral DNA Framework with Programmable Surface Modification.
J Am Chem Soc
August 2024
Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Article Synopsis
- Surface modification can improve how effectively nanovehicles deliver genes or drugs to cells, but it's not clear how different surface parameters affect this process.
- The study focuses on a specific DNA structure shaped like an icosahedron and tests three types of ligands with varying properties to see how they impact cell entry and processing by the cell.
- By comparing these different modifications, the research provides valuable insights into how to design more effective DNA nanostructures for targeted delivery in therapeutic applications.
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