Relaxin was secreted episodically in all 6 human subjects studied. A 24-hr rhythm was detected in the pooled data, with maximum secretion in the early-midmorning hours and a nadir in the early evening.
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Relaxin concentrations in serum and urine of endangered and crazy mixed-up species.
Ann N Y Acad Sci
April 2009
Department of Environmental Medicine, NYU School of Medicine, Tuxedo, New York 10987, USA.
The human population explosion has pushed many mammalian wildlife species to the brink of extinction. Conservationists are increasingly turning to captive breeding as a means of preserving the gene pool. We previously reported that serum immunoactive relaxin provided a reliable means of distinguishing between true and pseudopregnancy in domestic dogs, and this method has since been found to be a reliable indicator of true pregnancy in endangered Asian and African elephants and Sumatran rhinoceroses.
View Article and Find Full Text PDFThe source and secretion of immunoactive relaxin in rat milk.
Exp Biol Med (Maywood)
May 2009
Department of Environmental Medicine, NYU School of Medicine, Nelson Institute of Environmental Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA.
The milk of many mammalian species contains hormones and growth factors in addition to nutrients and immunocompetent substances. These factors can be absorbed into the circulation of suckling neonates to exert important effects on metabolism and promote tissue and organ growth. Frequently, there is uncertainty as to whether such substances are gene products of the mammary glands themselves or are produced elsewhere and concentrated from the systemic circulation.
View Article and Find Full Text PDFTransmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity.
Am J Vet Res
January 2008
Nelson Institute of Environmental Medicine, School of Medicine, New York University, Tuxedo, NY 10987, USA.
Objective: To determine whether abnormal laxity of hip joints of canine pups with genetic predisposition to hip dysplasia (HD+) is related to ingestion of milk-borne hormones.
Animals: 7 female Labrador Retrievers with HD+ and 8 with low predisposition to hip dysplasia (HD-) and their offspring.
Procedures: Immunoactive relaxin, estrogen, and estrogen precursor concentrations in milk of HD+ lactating bitches and in serum of their pups were compared with those of HD- bitches and pups.
Abnormal relaxin secretion during pregnancy in women with type 1 diabetes.
Exp Biol Med (Maywood)
January 2003
Department of Obstetrics and Cleft Palate Research Unit, Royal Victoria Infirmary, Newcastle, Tyne and Wear, NE1 4LP, United Kingdom.
To test the hypothesis that relaxin may play a role in the fetal abnormalities associated with pregnancy in type 1 diabetic women, we previously compared gestational relaxin concentrations in diabetic and clinically normal women using a porcine relaxin radioimmunoassay (RIA): Serum immunoactive relaxin was significantly (P < 0.001) elevated in the diabetic women. To confirm and extend this work in a larger group of subjects, we have now used an enzyme-linked immunosorbent assay (ELISA) specific for human H2 relaxin (the normal human gene product) to determine immunoactive serum relaxin concentrations in serial samples from 61 Type 1 diabetic and 21 normal pregnant women.
View Article and Find Full Text PDFDogfish shark (Squalus acanthias) testes contain a relaxin.
J Androl
May 1998
Department of Environmental Medicine, New York University Medical Center, Tuxedo 10987, USA.
Relaxin is a 6-kd polypeptide that exerts important hormonal effects in many female mammals. Relaxin is produced by the ovary, placenta, or uterus in many mammalian species. The functions of relaxin in the male mammal are not yet firmly established, but there is some evidence suggesting an exocrine effect on sperm motility and fertilizability.
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