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Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
J Pharm Anal
October 2024
Department of Dermatology, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
Tetrandrine (TET), a natural bisbenzyl isoquinoline alkaloid extracted from S. Moore, has diverse pharmacological effects. However, its effects on melanoma remain unclear.
View Article and Find Full Text PDFAstragaloside IV inhibits retinal pigment epithelial cell senescence and reduces IL-1β mRNA stability by targeting FTO-mediated mA methylation.
Phytomedicine
January 2025
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China; Department of Ophthalmology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, China. Electronic address:
Background: Resistance to senescence in retinal pigment epithelial (RPE) cells can delay the progression of age-related macular degeneration (AMD). However, the mechanisms underlying RPE cell senescence remain inadequately understood, and effective therapeutic strategies are lacking. While astragaloside IV (Ast) has demonstrated anti-aging properties, its specific effects on RPE cell senescence and potential mechanisms are not yet fully clarified.
View Article and Find Full Text PDFGlobal 3D model of mantle attenuation using seismic normal modes.
Nature
January 2025
Department of Earth Sciences, Utrecht University, Utrecht, The Netherlands.
Seismic tomographic models based only on wave velocities have limited ability to distinguish between a thermal or compositional origin for Earth's 3D structure. Complementing wave velocities with attenuation observations can make that distinction, which is fundamental for understanding mantle convection evolution. However, global 3D attenuation models are only available for the upper mantle at present.
View Article and Find Full Text PDFIntranasal Administrations of AP39-Loaded Liposomes Selectively Deliver H2S to Neuronal Mitochondria to Protect Neonatal Hypoxia-Ischemia by Targeting ERK1/2 and Caspase-1.
ACS Biomater Sci Eng
January 2025
Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
Mitochondrial dysfunction contributes to the pathology of hypoxia-ischemia (HI) brain damage by aberrant production of ROS. Hydrogen sulfide (HS) has been demonstrated to exert neuroprotective effects through antioxidant mechanisms. However, the diffusion of HS is not specifically targeted and may even be systemically toxic.
View Article and Find Full Text PDFEffective removal of As from aqueous medium using date palm fiber biochar/chitosan/glutamine nanocomposite: kinetic and thermodynamic studies.
Environ Sci Pollut Res Int
January 2025
Chemistry Department, Faculty of Science, Damanhour University, Damanhour, Egypt.
In the current work, three adsorbent materials were developed: biochar derived from date palm fiber (C), date palm fiber biochar/chitosan nanoparticles (CCS), and biochar/chitosan nanoparticle composite supplemented with glutamine (CCSG). These compounds were used as solid adsorbents to remove As from polluted water. Several characterization approaches were used to investigate all the synthesized solid adsorbents, including thermogravimetric analysis, N adsorption/desorption isotherm, scanning electron microscopy, transmission electron microscopy (TEM), attenuated total reflectance with Fourier transform infrared, and zeta potential.
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