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http://dx.doi.org/10.1103/physrevb.32.5776 | DOI Listing |
Peptide therapeutics, a major class of medicines, have achieved remarkable success across diseases such as diabetes and cancer, with landmark examples such as GLP-1 receptor agonists revolutionizing the treatment of type-2 diabetes and obesity. Despite their success, designing peptides that satisfy multiple conflicting objectives, such as target binding affinity, solubility, and membrane permeability, remains a major challenge. Classical drug development and structure-based design are ineffective for such tasks, as they fail to optimize global functional properties critical for therapeutic efficacy.
View Article and Find Full Text PDFMitochondrial DNA (mtDNA) plays a crucial role in numerous cellular processes, yet its impact on human behavior remains underexplored. The current paper proposes a novel covariance structure model with seven parameters to specifically isolate and quantify mtDNA effects on human behavior. This approach uses extended pedigrees to obtain estimates of mtDNA variance while controlling for other genetic and environmental influences.
View Article and Find Full Text PDFPhys Med Biol
January 2025
Radiology, Stanford University, 1201 Welch Rd, P270, Stanford, California, 94305-6104, UNITED STATES.
Radiation dose and diagnostic image quality are opposing constraints in x-ray CT. Conventional methods do not fully account for organ-level radiation dose and noise when considering radiation risk and clinical task. In this work, we develop a pipeline to generate individualized organ-specific dose and noise at desired dose levels from clinical CT scans.
View Article and Find Full Text PDFPhys Med Biol
January 2025
Medical Physics Laboratory, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, Goudi, Athens, Attica, 11527, GREECE.
Clinical dosimetry in the presence of a 1.5T magnetic field is challenging, let alone in case small fields are involved. The scope of this study is to determine a set of relevant correction factors for a variety of MR-compatible detectors with emphasis on small fields.
View Article and Find Full Text PDFRev Sci Instrum
January 2025
National Institute of Metrology, Beijing 100029, China.
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