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Updates on Intrinsic Medicinal Chemistry of 1,4-dihydropyridines, Perspectives on Synthesis and Pharmacokinetics of Novel 1,4-dihydropyrimidines as Calcium Channel Blockers: Clinical Pharmacology.
Curr Top Med Chem
January 2025
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.
Background: Several chemical studies described the physiological efficacy of 1,4- dihydropyridines (DHPs). DHPs bind to specific sites on the α1 subunit of L-type calcium channels, where they demonstrate a more pronounced inhibition of Ca2+ influx in vascular smooth muscle compared to myocardial tissue. This selective inhibition is the basis for their preferential vasodilatory action on peripheral and coronary arteries, a characteristic that underlies their therapeutic utility in managing hypertension and angina.
View Article and Find Full Text PDFMitigating high frame rate demands in shear wave elastography using radial basis function-based reconstruction: An experimental phantom study.
Ultrasonics
December 2024
Department of Information Engineering and Computer Science, University of Trento, Italy.
Background: Shear wave elastography (SWE) is a technique that quantifies tissue stiffness by assessing the speed of shear waves propagating after being excited by acoustic radiation force. SWE allows the quantification of elastic tissue properties and serves as an adjunct to conventional ultrasound techniques, aiding in tissue characterization. To capture this transient propagation of the shear wave, the ultrasound device must be able to reach very high frame rates.
View Article and Find Full Text PDFEnhanced Antimicrobial Efficiency of Gold Nanoclusters via Improved Sonodynamic Activity and Out-Membrane Crossing Capacity.
Nano Lett
December 2024
Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China.
Article Synopsis
- Antimicrobial sonodynamic therapy (SDT) shows potential in clinical settings due to its safety, noninvasiveness, and lack of resistance issues, but finding efficient sonodynamic sensitizers is challenging.
- Researchers have introduced gold nanoclusters (Au NCs) as promising sonodynamic sensitizers, demonstrating significant antimicrobial effectiveness for infected wound treatment.
- The combination of l-arginine (Arg) and 6-azido-2-thiothymidine (ATT) with Au NCs enhances their structural strength and increases reactive oxygen species (ROS) production, resulting in a dramatic reduction of microbial viability inside bacterial cells.
Slow global motions in biosolids studied by the deuteron stimulated echo NMR experiment.
J Chem Phys
November 2024
Institut für Physik, Martin-Luther-Universität Halle-Wittenberg, Betty-Heimann-Str. 7, 06120 Halle (Saale), Germany.
Recent 15N R1ρ-relaxation studies have shown that proteins in the solid state undergo slow, low amplitude global motion in the sub-millisecond time range. This range is at the edge of the time window for R1ρ experiments and, therefore, the motional parameters obtained by this method are not precise or reliable. In this paper, we present a 2H stimulated echo study of this type of molecular dynamics.
View Article and Find Full Text PDFGABA (γ-aminobutyric acid) enrichment and detection methods in cereals: Unlocking sustainable health benefits.
Food Chem
February 2025
School of Food and Biological Engineering Jiangsu University, Zhenjiang, Jiangsu 212013, China. Electronic address:
Gamma-aminobutyric acid (GABA), a non-protein amino acid primarily biosynthesized in cereals, is vital to the human neurological system. As the primary neurotransmitter, it promotes relaxation, inhibits depression and sleeplessness, and regulates synaptic transmission and neuronal development. GABA also protects the liver, kidneys, and intestines, reduces blood pressure, and fights cancer and inflammation.
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