Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D2A, D3) and 5HT1A receptors were evaluated for their ability to displace [3H]-raclopride and [3H]-8-OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5-HT1A > D2 > D3.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(98)00646-5 | DOI Listing |
Publication Analysis
Top Keywords
phenylpiperazine derivatives
4
derivatives strong
4
strong affinity
4
affinity 5ht1a
4
5ht1a d2a
4
d2a receptors
4
receptors 7-[3-4-phenyl-1-piperazinylpropoxy]coumarins
4
7-[3-4-phenyl-1-piperazinylpropoxy]coumarins synthesized
4
synthesized affinities
4
affinities compounds
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!