AI Article Synopsis
- Parkinsonism is linked to several neurodegenerative diseases, notably Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy, which all indicate issues with the dopaminergic neurotransmitter system.
- Advances in imaging techniques like SPET and PET allow for in-vivo visualization of dopaminergic neurons and dopamine D2 receptors, which enhances diagnostic capabilities for parkinsonian syndromes.
- This review focuses on how SPET and PET studies contribute to understanding and diagnosing the dopaminergic system's role in different parkinsonian conditions.
Article Abstract
Parkinsonism is a feature of a number of neurodegenerative diseases, including Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. The results of post-mortem studies point to dysfunction of the dopaminergic neurotransmitter system in patients with parkinsonism. Nowadays, by using single-photon emission tomography (SPET) and positron emission tomography (PET) it is possible to visualise both the nigrostriatal dopaminergic neurons and the striatal dopamine D2 receptors in vivo. Consequently, SPET and PET imaging of elements of the dopaminergic system can play an important role in the diagnosis of several parkinsonian syndromes. This review concentrates on findings of SPET and PET studies of the dopaminergic neurotransmitter system in various parkinsonian syndromes.
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| http://dx.doi.org/10.1007/s002590050374 | DOI Listing |
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