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Heyde's syndrome (HS) represents an association between aortic stenosis and intestinal angiodysplasias, and it has been demonstrated that acquired von Willebrand disease plays a pivotal role in the pathophysiology of this syndrome. In patients with HS, von Willebrand factor deficiency represents an additional risk factor, further contributing to the risk of bleeding and anemia. We present the case of an 86-year-old patient diagnosed with HS and von Willebrand deficiency in 2018.

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"Heyde's enigma" in a patient with congenital annular aortic stenosis and its therapeutic challenges.

Indian J Thorac Cardiovasc Surg

May 2024

Department of Cardiothoracic Surgery, Manipal Hospital, Old Airport Road, Bengaluru, Karnataka 560017 India.

Unlabelled: Heyde's syndrome is described as angio-dysplastic gastrointestinal (GI) bleeding in elderly patients with degenerative severe calcific aortic stenosis (AS), resulting in anaemia. It was first reported by Edward C. Heyde in 1958 and thus carried his name.

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We present a case report of a 59-year-old woman with multiple gastrointestinal stromal tumors as a cause of gastrointestinal bleeding. She initially presented with recurrent iron deficiency anemia and subsequent gastrointestinal bleeding over 10 years. An initial angiodysplastic lesion was identified, treated, and spot tattooed.

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Article Synopsis
  • Heyde syndrome links aortic stenosis with gastrointestinal bleeding caused by angiodysplasia, first identified in 1958.
  • A case study discusses an 86-year-old woman who experienced gastrointestinal bleeding due to colonic angiodysplasia, linked to her severe aortic stenosis.
  • The literature review indicates differing views on whether the conditions are directly related or coincidental, but larger studies lean towards supporting a causative relationship.
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The misclassification of gastric antral vascular ectasia.

J Clin Transl Res

June 2022

Department of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama, United States.

Background: Gastric antral vascular ectasia (GAVE) is characterized by angiodysplastic lesions and is a rare form of gastrointestinal bleeding. Given the multiple patterns, GAVE can be misclassified.

Aim: We analyzed the misclassification of GAVE among patients undergoing esophagogastroduodenoscopy (EGD).

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