Glycine plays an important role as a neurotransmitter in the four vestibular nuclei (VN). The objective of this study was to determine if the levels of glycine-receptor binding in the VN change as a function of age. Quantitative receptor autoradiography was performed on brainstem sections from three age groups (3, 18 and 26 months) of Fischer 344 rats to assess binding in the VN. Glycine receptors were localized using [3H]strychnine binding. Strychnine binding declined monotonically with increasing age, such that the level of strychnine binding in each of the VN in the 28-month-old animals was approximately one-half that in the 3-month-olds. The age-related decrease in levels of strychnine binding suggest altered glycinergic function in the VN, which may in turn contribute to disturbances in equilibrium observed in the elderly.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0378-5955(98)00177-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
VirtuousPocketome: a computational tool for screening protein-ligand complexes to identify similar binding sites.
Sci Rep
March 2024
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, PolitoBIOMedLab, 10129, Torino, Italy.
Protein residues within binding pockets play a critical role in determining the range of ligands that can interact with a protein, influencing its structure and function. Identifying structural similarities in proteins offers valuable insights into their function and activation mechanisms, aiding in predicting protein-ligand interactions, anticipating off-target effects, and facilitating the development of therapeutic agents. Numerous computational methods assessing global or local similarity in protein cavities have emerged, but their utilization is impeded by complexity, impractical automation for amino acid pattern searches, and an inability to evaluate the dynamics of scrutinized protein-ligand systems.
View Article and Find Full Text PDFBrucine alleviates fibroblast-like synoviocytes dysfunction and inflammation by regulating YY1 during rheumatoid arthritis.
Chem Biol Drug Des
March 2024
Department of TCM, Changzhou Cancer Hospital, Changzhou, China.
Brucine is a weak alkaline indole alkaloid with wide pharmacological activities and has been identified to protect against rheumatoid arthritis (RA) process. Circular RNAs (circRNAs) are also reported to be involved in the pathogenesis of RA. Here, we aimed to probe the role and mechanism of Brucine and circ_0139658 in RA progression.
View Article and Find Full Text PDFExploring promising natural compounds for breast cancer treatment: molecular docking targeting WDR5-MYC protein interaction.
J Biomol Struct Dyn
February 2024
Department of Life Sciences, Sharda School of Basic Sciences and Research, Sharda University, Uttar Pradesh, India.
Cancer is an aberrant differentiation of normal cells, characterized by uncontrolled growth and the potential to acquire invasive and aggressive properties that ultimately lead to metastasis. In the realm of scientific exploration, a multitude of pathways has been investigated and targeted by researchers, among which one specific pathway is recognized as WDR5-MYC. Continuous investigations and research show that WDR5-MYC is a therapeutic target protein.
View Article and Find Full Text PDFIsolation and spectral characterisation of bioactives from sea weed . - using & high throughput analytical techniques.
Nat Prod Res
December 2023
Department of Pharmaceutical Chemistry, Acharya B.M. Reddy College of Pharmacy, Bengaluru, Karnataka, India.
This work is the first report dealing with the identification and characterisation of the secondary metabolites of the ethanolic extract of The ethanolic extract of was analysed by LCMS& Direct mass spectral analysis which is allowed to identify and Interpreted 6 & 15 compounds. The main constituents were caffeic acid, rosemary acid, Perilic acid, strychnine, hydroxy stearic acid, respectively. The extract further purified by column chromatography 15 fractions was isolated, out of which Perilic acid and strychnine are in high quantities.
View Article and Find Full Text PDFRepurposing of Strychnine as the Potential Inhibitors of Aldo-keto Reductase Family 1 Members B1 and B10: Computational Modeling and Pharmacokinetic Analysis.
Protein J
April 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
AKR1B1 and AKR1B10 are important members of aldo-keto reductase family which plays a significant role in cancer progression by modulating cellular metabolism. These enzymes are involved in various metabolic processes, including the synthesis and metabolism of hormones, detoxification of reactive aldehydes, and the reduction of various endogenous and exogenous compounds. This study aimed to explore the potential of strychnine as an anticancer agent by targeting AKR1B1 and AKR1B10 via drug repurposing approach.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!