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Clinical and bacteriological characteristics of Corynebacterium keratitis.
J Ophthalmic Inflamm Infect
January 2025
Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
Purpose: Corynebacterium species are commensals of human skin and mucous membranes and are recognized as important pathogens in ocular infections. This study investigated the clinical characteristics of Corynebacterium keratitis.
Methods: We retrospectively reviewed cases of bacterial keratitis in which Corynebacterium species were solely isolated from corneal scraping cultures collected at Ehime University Hospital between January 2010 and February 2024.
"Control of industrially relevant microbial isolates by antimicrobial agents: implications for sugar factories.".
J Ind Microbiol Biotechnol
January 2025
National Center for Agricultural Utilization Research, Peoria, IL 61604, USA.
Microbial isolates from sugar crop processing facilities were tested for sensitivity to several industrial antimicrobial agents to determine optimal dosing. Hydritreat 2216 showed broad spectrum activity against all bacterial isolates as well as Saccharomyces cerevisiae. Sodium hypochlorite showed broad spectrum activity against all isolates, but at much higher effective concentrations.
View Article and Find Full Text PDFBacteria associated with canine pyometra and concurrent bacteriuria: A prospective study.
Vet Microbiol
December 2024
Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57 (Viikintie 49), Helsinki FI-00014, Finland.
Canine pyometra is a common and potentially life-threatening reproductive disorder in intact female dogs. This prospective study aimed to (1) investigate the bacterial spectrum and antimicrobial susceptibilities of bacterial isolates from the uterus and urine of dogs with pyometra, (2) assess the clonal relatedness and virulence factors of Escherichia coli isolates from individual dogs, and (3) determine the occurrence of concurrent and persistent bacteriuria or clinical urinary tract infections. Bacterial isolates from 208 uterine and 203 urine specimens collected during pyometra surgery were analyzed.
View Article and Find Full Text PDFWeakened Airway Epithelial Junctions and Enhanced Neutrophil Elastase Release Contribute to Age-Dependent Bacteremia Risk Following Pneumococcal Pneumonia.
Aging Cell
January 2025
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
Streptococcus pneumoniae (Sp; pneumococcus), the most common agent of community-acquired pneumonia, can spread systemically, particularly in the elderly, highlighting the need for adjunctive therapies. The airway epithelial barrier defends against bacteremia and is dependent upon apical junctional complex (AJC) proteins such as E-cadherin. After mouse lung challenge, pneumolysin (PLY), a key Sp virulence factor, stimulates epithelial secretion of an inflammatory eicosanoid, triggering the infiltration of polymorphonuclear leukocytes (PMNs) that secrete high levels of neutrophil elastase (NE), thus promoting epithelial damage and systemic infection.
View Article and Find Full Text PDFMolecular and genetic analysis of methicillin-resistant Staphylococcus aureus (MRSA) in a tertiary care hospital in Saudi Arabia.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Microbiology, Hind Institute of Medical Sciences, Mau, Ataria, Sitapur, Uttar Pradesh, India, 261303.
Methicillin-resistant Staphylococcus aureus (MRSA) continues to pose significant challenges in healthcare settings due to its multi-drug resistance (MDR) and virulence. This retrospective study examines the molecular and resistance profiles of MRSA isolates from a tertiary care hospital in Saudi Arabia, providing valuable insights into regional epidemiology. A total of 190 MRSA strains were analysed to assess antimicrobial susceptibility, genetic diversity, and virulence factors.
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