Depression, a chronic disease and a leading cause of disability worldwide, will generate increasing needs in terms of public health in the coming years. Many antidepressants are now available. However, these molecules present real limitations and disadvantages. Thus there are great expectations on the part of the clinicians for more efficient drugs that are better tolerated. How can we satisfy such hopes and innovate in this domain today? One original and most promising strategy for developing new antidepressants that are more efficient and better tolerated involves antagonizing both alpha 2-noradrenergic and 5HT2 and 5HT3 serotonergic receptors, without blocking 5HT1A serotonergic receptors. The technology now available in pharmacological research allows the development of such molecules.
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NH-Modulated Cathodic Interfacial Spatial Charge Redistribution for High-Performance Dual-Ion Capacitors.
Nanomicro Lett
January 2025
Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China.
Compared with Zn, the current mainly reported charge carrier for zinc hybrid capacitors, small-hydrated-sized and light-weight NH is expected as a better one to mediate cathodic interfacial electrochemical behaviors, yet has not been unraveled. Here we propose an NH-modulated cationic solvation strategy to optimize cathodic spatial charge distribution and achieve dynamic Zn/NH co-storage for boosting Zinc hybrid capacitors. Owing to the hierarchical cationic solvated structure in hybrid Zn(CFSO)-NHCFSO electrolyte, high-reactive Zn and small-hydrate-sized NH(HO) induce cathodic interfacial Helmholtz plane reconfiguration, thus effectively enhancing the spatial charge density to activate 20% capacity enhancement.
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Dermatology department, Hôpital Erasme-HUB.
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Ectopic overexpression of DNA-/RNA-binding Alba proteins misregulates virulence gene homeostasis during asexual blood development.
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Institute of Bioinformatics and Applied Biotechnology, Bengaluru, Karnataka, India.
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View Article and Find Full Text PDFHypothermic machine perfusion in uterus transplantation in a porcine model: A proof of concept and the first results in graft preservation.
Acta Obstet Gynecol Scand
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Department of Gynecology, Rennes University Hospital, Hôpital Sud, Rennes, France.
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Oral Microbiology, Bristol Dental School, University of Bristol, United Kingdom.
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