Four of 688 consecutive patients with right hemisphere ischemic stroke showed acute associated exploratory-motor and perceptual-sensory neglect without hemiparesis (AMSNWH). All cases had anterior cortical and posterior cortical infarctions in which motor strip and corticospinal pathways were spared. Acute AMSNWH is highly suggestive of embolic infarction in the anterior and posterior pial artery territories.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1212/wnl.52.1.199 | DOI Listing |
PLoS Comput Biol
October 2024
Department of Mechanical Engineering, University of Delaware, Newark, Delaware, United States of America.
Behav Brain Res
August 2023
Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany. Electronic address:
Rearing, i.e., standing on the hind limbs in an upright posture, is part of a rat's innate exploratory motor program.
View Article and Find Full Text PDFJ Pharmacol Exp Ther
August 2021
Departments of Anatomy and Neurobiology (Y.F., D.P.), Biological Chemistry (D.P.), and Pharmaceutical Sciences (D.P.), University of California, Irvine, California; Drug Discovery and Development, Istituto Italiano di Technologia, Genova, Italy (O.S.); and School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy (R.C.)
-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase that stops the physiologic actions of palmitoylethanolamide, an endogenous lipid messenger that activates the transcription factor, peroxisome proliferator-activated receptor- We have previously reported that the compound ARN19702 [(2-ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone] is an orally active, reversible NAAA inhibitor (IC on human NAAA = 230 nM) that produces remarkable protective effects against multiple sclerosis in mice. In the present study, we assessed the profile of ARN19702 in mouse and rat models of acute and neuropathic pain. Oral administration in male mice attenuated in a dose-dependent manner the spontaneous nocifensive response elicited by intraplantar formalin injection and the hypersensitivity caused by intraplantar carrageenan injection, paw incision, or sciatic nerve ligation.
View Article and Find Full Text PDFBraz J Phys Ther
September 2021
School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA. Electronic address:
Background: The timing and coordination of infant kicking may allow for activities that facilitate learning and cognitive development.
Objective: This study examined spontaneous kicking and associations with changes in kicking during a learning paradigm in typically developing infants.
Methods: Ten healthy full-term infants participated in two experiments at 3 months of age: spontaneous kicking and the mobile paradigm.
J Ethnopharmacol
February 2021
School of Health Sciences, Federal University of Grande Dourados - Dourados, Mato Grosso do Sul State, Brazil. Electronic address:
Ethnopharmacological Relevance: In the State of Mato Grosso do Sul, the watery sap of Doliocarpus dentatus is used to alleviate thirst, and the leaves of this species are used to relieve pain and swelling associated with inflammatory processes.
Aim Of The Study: This study aimed to analyze the compounds of the leaves from the aqueous extract of D. dentatus (EADd) and evaluate its toxicogenetic and pain relief effects in animal models.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!