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Population pharmacokinetics of butorphanol following intramuscular administration to exercised thoroughbred horses.
J Vet Pharmacol Ther
September 2024
School of Veterinary Medicine, University of California, Davis, California, USA.
Butorphanol is commonly administered, both by the intravenous and intramuscular routes, to racehorses to facilitate handling for diagnostic procedures. As the administration of butorphanol for therapeutic purposes is considered appropriate, in order to avoid inadvertent positive drug tests, a thorough understanding of the pharmacokinetics of this drug is necessary. In the current study, 12, exercised Thoroughbred horses were administered a single intramuscular dose of 0.
View Article and Find Full Text PDFSedation with dexmedetomidine-butorphanol or xylazine-butorphanol continuous intravenous infusions during unilateral ovariectomy in standing donkeys.
Equine Vet J
November 2024
Clinical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis.
Background: Intravenous infusions of alpha-2 adrenoceptor sedatives and opioids can potentially facilitate surgery in donkeys while standing. Literature on this subject matter is scant.
Objectives: Evaluation of efficacy of sedation from α-adrenoceptors (dexmedetomidine or xylazine) and butorphanol during ovariectomy in standing donkeys.
Sedative and cardiopulmonary effects of intranasal butorphanol with midazolam or dexmedetomidine in New Zealand white rabbits.
Vet Rec
July 2023
Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey.
Background: This study aimed to compare the sedative and cardiopulmonary effects of intranasal (IN) administration of dexmedetomidine-butorphanol (DB) and midazolam-butorphanol (MB) combinations in New Zealand white rabbits.
Methods: Eight New Zealand white rabbits were sedated by IN administration of a combination of 0.1 mg/kg dexmedetomidine and 0.
Pharmacokinetics of intravenous propofol in southern white rhinoceros (Ceratotherium simum simum) after intramuscular etorphine-butorphanol-medetomidine-azaperone.
Am J Vet Res
April 2023
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.
Objective: To determine the pharmacokinetics of a single bolus of intravenous (IV) propofol after intramuscular administration of etorphine, butorphanol, medetomidine, and azaperone in 5 southern white rhinoceros to facilitate reproductive evaluations. A specific consideration was whether propofol would facilitate timely orotracheal intubation.
Animals: 5 adult, female, zoo-maintained southern white rhinoceros.
Using a combination of midazolam and butorphanol is a safe and effective reversible field sedation protocol for Weddell seal (Leptonychotes weddellii) pups.
Vet Rec
December 2022
The Marine Mammal Center, Sausalito, California, USA.
Background: Weddell seals (Leptonychotes weddellii) are a well-studied species of phocid with an apparent sensitivity to immobilising agents. Mortality as high as 31% has been reported during field immobilisation. This study investigated the use of a benzodiazepine in combination with an opioid agonist/antagonist for sedation in Weddell seal pups as part of a physiological study.
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