This review focuses on new developments in the understanding of how oropharyngeal and postingestional stimulation control the ingestive behavior of the rat ingesting liquids. With the development of the computer-controlled lickometer it is now possible to measure and analyze in fine detail the impact these two variables have on the rat's licking behavior. Because variations in this behavior are responsible for variations in intake this methodology is beginning to provide a clearer picture of how oropharyngeal and postingestional stimulation control ingestive behavior and interact to control meal size. These developments should in turn ultimately provide the basis for better understanding of how the motor systems of the brain control the behavior that supplies the body with its nutrients.
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http://dx.doi.org/10.1016/s0899-9007(98)00109-9 | DOI Listing |
Chem Senses
November 2009
Department of Cell and Developmental Biology, University of Colorado Denver, MS 8108, PO Box 6511, Aurora, CO 80045-6511, USA.
Mice lacking the purinergic receptors, P2X2 and P2X3 (P2X2/P2X3(Dbl-/-)), exhibit essentially no tastant-evoked activity in the chorda tympani and glossopharyngeal nerves and substantial loss of tastant-evoked behavior as measured in long-term intake experiments. To assess whether the residual chemically driven behaviors in these P2X2/P2X3(Dbl-/-) mice were attributable to postingestive detection or oropharyngeal detection of the compounds, we used brief access lickometer tests to assess the behavioral capabilities of the P2X2/P2X3(Dbl-/-) animals. The P2X2/P2X3(Dbl-/-) mice showed avoidance to high levels (10 mM quinine and 10-30 mM denatonium benzoate) of classical "bitter"-tasting stimuli in 24-h, 2-bottle preference tests but minimal avoidance of these substances in the lickometer tests, suggesting that the strong avoidance in the intake tests was largely mediated by post-oral chemosensors.
View Article and Find Full Text PDFPhysiol Behav
September 2008
Department of Physiology, Faculty of Biology, University of Murcia, 30100, Murcia, Spain.
The use of a single diet with a well defined composition to feed fish throughout their life cycle is an oversimplification that probably does not respond to their metabolic requirements. For example, the seasonal reproduction that characterizes most fish species demands changes in nutritional requirements. Bearing this in mind, the macronutrient selection pattern was studied from January to August in twelve individually housed sea bass exposed to a constant photoperiod (12L:12D h) and temperature (23+/-0.
View Article and Find Full Text PDFPhysiol Behav
July 2006
Department of Physiology, Faculty of Biology, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain.
Sharpsnout seabream ability for macronutrient self-selection was studied using gelatine capsules containing pure macronutrients. In particular, the existence of non-oropharyngeal chemosensory pathways involved on protein (P), fat (F) and carbohydrate (CH) selection, as well as sharpsnout seabream response to dietary protein dilution were investigated. In a sequence of experimental phases, sharpsnout seabream were fed a pelleted complete diet, an encapsulated complete diet or a combination of separately encapsulated pure macronutrients.
View Article and Find Full Text PDFPhysiol Behav
June 2005
School of Psychology, University of Liverpool, Eleanor Rathbone Building, Liverpool L69 7ZA, UK.
The aim of this study was to investigate, for the first time, the effects of a centrally active benzodiazepine receptor agonist, midazolam maleate, on the microstructure of licking responses for a range of sodium chloride (NaCl) solutions in mildly water-deprived male rats. Doses of midazolam were chosen (0.3-3.
View Article and Find Full Text PDFPhysiol Behav
March 2005
Department of Physiology, Faculty of Biology, University of Murcia, Campus de Espinardo, 30100-Murcia, Spain.
Recent reports describe teleosts as being able to regulate energy intake by selecting from pure macronutrient sources, although the regulatory mechanisms involved in this selection remain unknown. The aim of the present work was to determine the effect of selective macronutrient deprivation on energy regulation and macronutrient selection, using for this purpose carbohydrate (CH), protein (P), and fat (F) packaged separately into gelatin capsules, a method that prevents the diet chemosensory properties at oropharyngeal level from interfering with macronutrient selection. Twenty-four individually housed sea bass (Dicentrarchus labrax) were subjected to two experiments: (a) two-macronutrient deprivation, and (b) one-macronutrient deprivation.
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