From the leaves of Stenochlaena palustris five new O-acylated flavonol glycosides, stenopalustrosides A-E (1-5), have been isolated along with five known compounds, kaempferol 3-O-(3' '-O-E-p-coumaroyl)-(6' '-O-E-feruloyl)-beta-D-glucopyranoside (6), kaempferol 3-O-(3' ',6' '-di-O-E-p-coumaroyl)-beta-D-glucopyranoside (7), kaempferol 3-O-(3' '-O-E-p-coumaroyl)-beta-D-glucopyranoside (8), kaempferol 3-O-(6' '-O-E-p-coumaroyl)-beta-D-glucopyranoside (9); and kaempferol 3-O-beta-D-glucopyranoside (10). The structures of the isolates were elucidated by spectroscopic methods, mainly 1D and 2D NMR. Compounds 1-4 showed significant antibacterial activities against Gram-positive strains. The structural difference between the isolated antibacterial and nonantibacterial compounds is discussed.
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http://dx.doi.org/10.1021/np980179f | DOI Listing |
Z Naturforsch C J Biosci
September 2023
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, 731-0153, Japan.
This study was to compare GABase [a mixture of -aminobutyric acid (GABA) aminotransferase and succinic semialdehyde dehydrogenase] and glutaminase inhibitory activities of 20 herbal extracts and investigate the isolation, structural elucidation and those inhibitory activities of three acylated flavonol monoglycosides from the selected extract of L. (laurel). On the basis of the NMR spectroscopic data and the ESI MS spectra together with the comparison with the literature values, three compounds were identified as kaempferol-3--(4″---coumaroyl)--l-rhamnopyranoside (), kaempferol-3--(3″,4″-di---coumaroyl)--l-rhamnopyranoside () and kaempferol-3--(2″,4″-di---coumaroyl)--l-rhamnopyranoside (), respectively.
View Article and Find Full Text PDFPhytother Res
September 2022
Cancer Institute of Integrated tradition Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Protein signaling complexes play important roles in prevention of several cancer types and can be used for development of targeted therapy. The roles of signaling complexes of phosphodiesterase 3B (PDE3B) and Rap guanine nucleotide exchange factor 3 (RAPGEF3), which are two important enzymes of cyclic adenosine monophosphate (cAMP) metabolism, in cancer have not been fully explored. In the current study, a natural product Kaempferol-3-O-(3'',4''-di-E-p-coumaroyl)-α-L-rhamnopyranoside designated as KOLR was extracted from Cinnamomum pauciflorum Nees leaves.
View Article and Find Full Text PDFJ Agric Food Chem
June 2022
Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.
Prev Nutr Food Sci
March 2021
Department of Food Science and Nutrition, Daegu Catholic University, Gyeongbuk 38430, Korea.
Chem Biodivers
March 2017
Centro CEMEC and Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, 27100, Pavia, Italy.
Accompanied by other rare compounds, a new iridoid dimer, named kurdnestorianoside (1), showing an unprecedented secologanol configuration, has been isolated for the first time from the Kurdish medicinal plant Pterocephalus nestorianus, which is used in Kurdistan for treating oral diseases and inflammation. The structure of 1 was established from 1D- and 2D-NMR spectroscopic data. Kaempferol 3-O-[3,6-di-O-(E)-p-coumaroyl]-β-d-glucopyranoside (7) showed a remarkable antiproliferative activity against several human tumor cell lines.
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