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Host-Parasite Interactions in -Infected Cells: Roles of Mitochondria, Microtubules, and the Parasitophorous Vacuole.
Int J Mol Sci
December 2024
Department of Biochemistry and Molecular Biology, Frederick P. Whiddon College of Medicine, Mobile, AL 36688, USA.
An intracellular protozoan, the Apicomplexan parasite () infects nucleated cells, in which it triggers the formation of a specialized membrane-confined cytoplasmic vacuole, named the parasitophorous vacuole (PV). One of the most prominent events in the parasite's intracellular life is the congregation of the host cell mitochondria around the PV. However, the significance of this event has remained largely unsolved since the parasite itself possesses a functional mitochondrion, which is essential for its replication.
View Article and Find Full Text PDFHepG2 spheroids cultured in alginate microcapsules as a model for exploring mitochondrial and glycolytic metabolism using the Seahorse XFe24 Analyzer.
Toxicol Mech Methods
January 2025
Department of Life Sciences, of the University of Coimbra, Coimbra, Portugal.
Mitochondria are affected by chemical substances and play a critical role in drug-induced liver injury (DILI). Chemical substances can have a significant impact on various cellular processes, such as the disruption of oxidative phosphorylation, oxidative stress, and alteration of glucose metabolism. Given the consequences of these effects, it is crucial to understand the molecular pathways of chemical substances in the context of hepatotoxicity to prevent and treat DILI.
View Article and Find Full Text PDFA randomized controlled trial to assess the efficacy of standardized tai chi in prefrail older adults with immunosenescence: design and protocol.
BMC Complement Med Ther
January 2025
Geriatric department, Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shi-er-qiao Road, Chengdu, 610072, Sichuan, China.
Background: Frailty is a common geriatric syndrome worldwide, and its early identification and intervention have important clinical significance. Resistance training has been recommended as an efficient means to combat loss of muscle strength and mass; however, it is often not a prioritized option for older adults. Tai chi is a well-known traditional Chinese exercise that has a beneficial impact on physical performance, balance ability, metabolism, and immune function.
View Article and Find Full Text PDF[Clinical Outcomes of Transurethral Water Vapor Energy Therapy with Rezumᵀᴹ System].
Hinyokika Kiyo
November 2024
The Department of Urology, Kitasato University School of Medicine.
We carefully reviewed and evaluated the efficacy of transurethral water vapor energy therapy (WAVE) with Rezumᵀᴹ system for treatment of benign prostatic hyperplasia. Between April and September 2023, 41 patients received WAVE under local anesthesia as day surgery at the outpatient department in our institution. The mean age as of operation was 78.
View Article and Find Full Text PDFComparative Neurodynamic Analysis of Spinal Energy Enhancement in Experienced Yoga Practitioners Using Various Breathing Techniques.
Cureus
November 2024
Internal Medicine, Mahatma Gandhi Institute of Medical Sciences, Wardha, IND.
Introduction: Yoga practices emphasize spinal energy's role in physical, mental, and spiritual well-being, suggesting specific techniques that can enhance energy flow along the spine. Modern research aims to validate these claims and understand the mechanisms behind these effects, potentially integrating them into contemporary healthcare models. This study explores the relationship between yoga breathing techniques, spinal energy dynamics, and health based on yoga philosophy and bioenergetics.
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