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Enhancing Spin-Transport Characteristics, Spin-Filtering Efficiency, and Negative Differential Resistance in Exchange-Coupled Dinuclear Co(II) Complexes for Molecular Spintronics Applications.
Inorg Chem
January 2024
Department of Chemistry, IIT Bombay, Powai, Mumbai 400076, India.
Single-molecule spintronics, where electron transport occurs via a paramagnetic molecule, has gained wide attention due to its potential applications in the area of memory devices to switches. While numerous organic and some inorganic complexes have been employed over the years, there are only a few attempts to employ exchange coupled dinuclear complexes at the interface, and the advantage of fabricating such a molecular spintronics device in the observation of switchable Kondo resonance was demonstrated recently in the dinuclear [Co(L)(hfac)] () complex (Wagner et al., .
View Article and Find Full Text PDFDynamical systems model of development of the action differentiation in early infancy: a requisite of physical agency.
Biol Cybern
April 2023
Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan.
Young infants are sensitive to whether their body movements cause subsequent events or not during the interaction with the environment. This ability has been revealed by empirical studies on the reinforcement of limb movements when a string is attached between an infant limb and a mobile toy suspended overhead. A previous study reproduced the experimental observation by modeling both the infant's limb and a mobile toy as a system of coupled oscillators.
View Article and Find Full Text PDFSomato-dendritic decoupling as a novel mechanism for protracted cortical maturation.
BMC Biol
June 2016
Division of Translational Neuroscience, Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada.
Background: Both human and animal data indicate that disruption of the endogenously slow maturation of temporal association cortical (TeA) networks is associated with abnormal higher order cognitive development. However, the neuronal mechanisms underlying the endogenous maturation delay of the TeA are poorly understood.
Results: Here we report a novel form of developmental plasticity that is present in the TeA.
Morphological Changes in Subcutaneous White Adipose Tissue After Severe Burn Injury.
J Burn Care Res
December 2016
From the *Shriners Hospitals for Children, Galveston, Texas; and †University of Texas Medical Branch, Galveston, Texas.
Severe burn injury produces a plethora of metabolic abnormalities which contribute to the prolonged morbidity of burn survivors. The authors have recently demonstrated trans-differentiation of white adipose tissue (WAT) after burn trauma, toward a more thermogenic phenotype. However, the impact of burn injury on subcutaneous WAT (sWAT) morphology in humans is unknown.
View Article and Find Full Text PDFCharacterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors.
Mol Pharmacol
July 2014
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (C.H.C., D.A.S., H.X., A.Q., C.C.F.); and Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (A.C.)
The M(4) receptor is a compelling therapeutic target, as this receptor modulates neural circuits dysregulated in schizophrenia, and there is clinical evidence that muscarinic agonists possess both antipsychotic and procognitive efficacy. Recent efforts have shifted toward allosteric ligands to maximize receptor selectivity and manipulate endogenous cholinergic and dopaminergic signaling. In this study, we present the pharmacological characterization of LY2119620 (3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy] thieno[2,3-b]pyridine-2-carboxamide), a M(2)/M(4) receptor-selective positive allosteric modulator (PAM), chemically evolved from hits identified through a M4 allosteric functional screen.
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