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http://dx.doi.org/10.1103/physreva.48.2315 | DOI Listing |
JACS Au
January 2025
Department of Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden.
Disordered regions are an important functional feature of many multidomain proteins. A prime example is proteins in membraneless organelles, which contain folded domains that engage in specific interactions and disordered low-complexity (LC) domains that mediate liquid-liquid phase separation. Studying these complex architectures remains challenging due to their conformational variability.
View Article and Find Full Text PDFRheumatol Adv Pract
January 2025
Rheumatology Unit, ERN ReCONNET Center, IRCCS Meyer Children's Hospital, Firenze, Italy.
Objectives: Two different European Reference Networks cover CTDs with paediatric onset, the European Reference Network on Rare and Complex Connective Tissue Diseases (ERN ReCONNET) and the European Reference Network on Rare Immunological Disorders (ERN RITA). The transition of care is a significant focus, with ReCONNET centres actively addressing this through updated programs. Despite these efforts, challenges persist.
View Article and Find Full Text PDFBMJ Oncol
September 2023
Department of Public Health, Institute of Tropical Medicine, Antwerpen, Belgium.
Objective: Breast, lung, colon cancers are the 'big killers' in oncology. Access to innovative treatments lags behind in low-income and middle-income countries. We investigated the geographic distribution of industry-sponsored trials; and whether results were reported in clinical trial registries.
View Article and Find Full Text PDFFuture Sci OA
December 2025
Janssen Research & Development LLC, Raritan, NJ, USA.
Background: Including racial and ethnic minorities in clinical trials is essential for advancing health equity. Despite progress, trials often do not mirror patient population demographics.
Methods: The National Library of Medicine's Clinical Trials database was queried for phase III trials of lung, colorectal, breast, and prostate cancers.
Environ Evid
January 2025
Modelling, Evidence and Policy RG, SNES, Newcastle University, Newcastle, NE1 7RU, UK.
Background: Riparian zones are vital transitional habitats that bridge the gap between terrestrial and aquatic ecosystems. They support elevated levels of biodiversity and provide an array of important regulatory and provisioning ecosystem services, of which, many are fundamentally important to human well-being, such as the maintenance of water quality and the mitigation of flood risk along waterways. Increasing anthropogenic pressures resulting from agricultural intensification, industry development and the expansion of infrastructure in tropical regions have led to the widespread degradation of riparian habitats resulting in biodiversity loss and decreased resilience to flooding and erosion.
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