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How SNARE proteins generate force to fuse membranes.
Biophys J
January 2025
Department of Chemical Engineering, Columbia University, New York, NY 10027. Electronic address:
Membrane fusion is central to fundamental cellular processes such as exocytosis, when an intracellular machinery fuses membrane-enclosed vesicles to the plasma membrane for contents release. The core machinery components are the SNARE proteins. SNARE complexation pulls the membranes together, but the fusion mechanism remains unclear.
View Article and Find Full Text PDFHuman-Centric Spatial Cognition Detecting System Based on Drivers' Electroencephalogram Signals for Autonomous Driving.
Sensors (Basel)
January 2025
School of Automation, Beijing Institute of Technology, Beijing 100081, China.
Existing autonomous driving systems face challenges in accurately capturing drivers' cognitive states, often resulting in decisions misaligned with drivers' intentions. To address this limitation, this study introduces a pioneering human-centric spatial cognition detecting system based on drivers' electroencephalogram (EEG) signals. Unlike conventional EEG-based systems that focus on intention recognition or hazard perception, the proposed system can further extract drivers' spatial cognition across two dimensions: relative distance and relative orientation.
View Article and Find Full Text PDFA Line of Sight/Non Line of Sight Recognition Method Based on the Dynamic Multi-Level Optimization of Comprehensive Features.
Sensors (Basel)
January 2025
School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China.
With the advent of the 5G era, high-precision localization based on mobile communication networks has become a research hotspot, playing an important role in indoor emergency rescue in shopping malls, smart factory management and tracking, as well as precision marketing. However, in complex environments, non-line-of-sight (NLOS) propagation reduces the measurement accuracy of 5G signals, causing large deviations in position solving. In order to obtain high-precision position information, it is necessary to recognize the propagation state of the signal before distance measurement or angle measurement.
View Article and Find Full Text PDFQuantum-enhanced time-domain spectroscopy.
Sci Adv
January 2025
James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK.
The time-resolved detection of mid- to far-infrared electric fields absorbed and emitted by molecules is among the most sensitive spectroscopic approaches and has the potential to transform sensing in fields such as security screening, quality control, and medical diagnostics. However, the sensitivity of the standard detection approach, which relies on encoding the far-infrared electric field into amplitude modulation of a visible or near-infrared probe laser pulse, is limited by the shot noise of the latter. This constraint cannot be overcome without using a quantum resource.
View Article and Find Full Text PDFSpatial Cognitive EEG Feature Extraction and Classification Based on MSSECNN and PCMI.
Bioengineering (Basel)
December 2024
School of Intelligence Science and Technology, University of Science and Technology Beijing, Beijing 100083, China.
With the aging population rising, the decline in spatial cognitive ability has become a critical issue affecting the quality of life among the elderly. Electroencephalogram (EEG) signal analysis presents substantial potential in spatial cognitive assessments. However, conventional methods struggle to effectively classify spatial cognitive states, particularly in tasks requiring multi-class discrimination of pre- and post-training cognitive states.
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