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Exceptional Point and Hysteresis in Perturbations of Kerr Black Holes.
Phys Rev Lett
December 2024
Universidade Federal de Pernambuco, Departamento de Física, 50670-901, Recife, Brazil.
We employ the isomonodromic method to study linear scalar massive perturbations of Kerr black holes for generic scalar masses Mμ and generic black hole spins a/M. We find that the longest-living quasinormal mode and the first overtone coincide for (Mμ)_{c}≃0.370 4981 and (a/M)_{c}≃0.
View Article and Find Full Text PDFEffects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial.
Drug Des Devel Ther
January 2025
Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Purpose: HA121-28, a novel multi-targeting tyrosine kinase inhibitor, has dual efficacy against tumor growth and neovascularization. The objectives of this study were to assess the effect of high-fat and high-calorie food on the pharmacokinetic (PK) profile and safety of HA121-28 tablet in healthy subjects.
Patients And Methods: A single-dose, randomized, open-label, two-period, crossover-designed phase I clinical trial was conducted.
Pharmacokinetics of Depemokimab Delivered by Safety Syringe Device or Autoinjector in Healthy Adults: A Phase I, Single-Dose Study.
Clin Pharmacol Drug Dev
January 2025
Clinical Research Unit, PPD, Austin, TX, USA.
Article Synopsis
- The study compared the bioavailability of the anti-interleukin-5 antibody depemokimab when delivered using a safety syringe device (SSD) versus an autoinjector (AI) in healthy adults.
- Both methods showed similar plasma concentration profiles and pharmacokinetic parameters, confirming that they are bioequivalent.
- Adverse events were minor and comparable between the two delivery methods, with headaches being the most common side effect, indicating both devices are safe for administering depemokimab.
Cylindrical microlens arrays are important optical elements for autostereoscopic display. Conventional fixed focal length cylindrical microlens arrays do not allow switching between 2D mode and 3D mode when constructing a 3D viewing zone. In contrast, cylindrical liquid crystal microlens arrays with zoom characteristics allow switching between 2D and 3D states, as well as adjusting the width of the sub-viewing zone.
View Article and Find Full Text PDFSafety and Immunogenicity of Omicron Protein Vaccines in mRNA-Vaccinated Adolescents: A Phase 3, Randomised Trial.
J Infect
January 2025
Research Your Health, 6020 West Parker Road, Suite 430, Plano, Texas, 75093, USA.
Objectives: Safety and immunogenicity assessment of updated monovalent and bivalent SARS-CoV-2 vaccines in adolescents.
Methods: This phase 3, double-blinded study randomised 12-<18-year-old participants, who received ≥2 prior doses of an approved/authorised mRNA-based COVID-19 vaccine, 1:1 to receive NVX-CoV2601 (XBB.1.
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