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Influence of physico-chemical properties of hydroxypropyl methylcellulose on quetiapine fumarate release from sustained release matrix tablets.
BMC Chem
November 2024
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, Egypt.
Article Synopsis
- Quetiapine fumarate is a short-acting antipsychotic that typically requires multiple daily doses; this study aims to create a copolymer for controlled delivery of the drug.
- Hydroxypropyl methylcellulose K15M (HPMC K15M) is added to the formulation to enhance patient compliance and reduce side effects, with varying concentrations tested between 10-30%.
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Theranostic dye entrapped in an optimized blended-polymer matrix for effective photodynamic inactivation of diseased cells.
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July 2024
Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Chennai, TN, 603103, India.
Despite the wide range of treatment options available for cancer therapy, including chemotherapy, radiation therapy, and surgical procedures, each of these treatments has a different side-effect profile and leaves the patient with no option but to choose. Due to their insensitivity and nonspecificity, conventional treatments damage normal cells together with cancer cells. In recent years, a significant amount of attention has been focused on photodynamic therapy (PDT) as a treatment for cancer and drug-resistant microbes.
View Article and Find Full Text PDFAlginate-Bentonite-Based Hydrogels Designed to Obtain Controlled-Release Formulations of Dodecyl Acetate.
Gels
May 2023
Department of Chemistry and Physics, Research Centre CIAIMBITAL, University of Almería, Agrifood Campus of International Excellence (ceiA3), Crta. Sacramento s/n, 04120 Almería, Spain.
Dodecyl acetate (DDA), a volatile compound present in insect sex pheromones, was incorporated into alginate-based granules to obtain controlled-release formulations (CRFs). In this research, not only was the effect of adding bentonite to the basic alginate-hydrogel formulation studied, but also that of the encapsulation efficiency on the release rate of DDA in laboratory and field experiments. DDA encapsulation efficiency increased as the alginate/bentonite ratio increased.
View Article and Find Full Text PDFLornoxicam-Loaded Chitosan-Decorated Nanoemulsion: Preparation and In Vitro Evaluation for Enhanced Transdermal Delivery.
Polymers (Basel)
May 2022
Department of Biological Sciences, Science and Arts College, King Abdulaziz University, Rabigh 25726, Saudi Arabia.
Nanoemulsions are promising drug delivery systems for the administration of poorly soluble drugs like lornoxicam (LRX) by oral or parenteral routes. Such formulations work perfectly for transdermal delivery of lornoxicam-type drugs. It has also been established that formulating such a delivery system is highly dependent on the presence, type, and concentration of excipients taking part in the formulation.
View Article and Find Full Text PDFPreparation and evaluation of functional allopurinol imprinted starch based biomaterials for transdermal drug delivery.
Int J Biol Macromol
April 2021
Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu 59626, Republic of Korea. Electronic address:
This study focuses on the synthesis of functional allopurinol (ALP) imprinted biomaterials for a transdermal drug delivery using mung bean starch (MBS), polyvinyl alcohol (PVA), sodium benzoate (SB) as a crosslinking agent, and poloxamer (PX) as a thermo-sensitive polymer. Prepared functional biomaterials were characterized and evaluated by SEM, FT-IR analysis, and physical properties. Results of ALP recognition properties indicated that adsorbed amounts (Q) of ALP on functional ALP imprinted biomaterials were 3.
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