AI Article Synopsis
- The study explored how general anesthetics impact the neuronal response to acetylcholine in guinea pig olfactory cortex slices.
- Acetylcholine excited a majority of prepiriform neurons, with its effects being blocked by atropine but not by other agents.
- Different anesthetics produced varying effects on acetylcholine sensitivity, with some enhancing and others having no consistent effect, indicating that anesthetics can influence neuronal excitability differently.
Article Abstract
1The effects of general anaesthetics on neuronal responses to iontophoretically-applied acetylcholine have been examined in slices of guinea-pig olfactory cortex maintained in vitro. 2 Acetylcholine excited 61% of the prepiriform neurones tested. The excitation was blocked by atropine, but not by dihydro-beta-erythroidine or gallamine. 3 Alphaxalone reversibly depressed the acetylcholine-sensitivity of prepiriform neurones. Pentobarbitone did not consistently depress the acetylcholine sensitivity of these cells. 4 Ether, methoxyflurane, trichloroethylene and halothane caused a dose-related augmentation of acetylcholine-induced firing. 5 These results show that general anaesthetics do not necessarily depress the sensitivity of nerve cells to all excitatory substances and that different anaesthetics may affect a particular excitatory process in various ways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1667534 | PMC |
| http://dx.doi.org/10.1111/j.1476-5381.1976.tb07712.x | DOI Listing |
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