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Sulfur traits in the plant microbiome: implications for sustainable agriculture.
Trends Microbiol
March 2025
Singapore Centre for Environmental Life Sciences Engineering, National University of Singapore, Singapore 117456, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117558, Singapore; NUS Environmental Research Institute, National University of Singapore, Singapore 117411, Singapore. Electronic address:
Owing to its biochemical flexibility, sulfur (S) is uniquely poised to fulfill versatile roles in plant-microbe interactions - impacting their metabolism with significant consequences for plant health and the global S cycle. We present evidence that the diversity of S-metabolic genes in plant-associated microbiomes (phytobiomes) is underappreciated, and plant niches are hotspots of bacterial S-metabolism with implications for S emissions. Building upon emerging findings, we posit that coordination of S-metabolism between plants and phytobiomes is a common mechanism for plant-microbe homeostasis and agriculturally beneficial microbial services.
View Article and Find Full Text PDFEnhancing the experience and outcomes of children with complex care needs in acute paediatric settings: a realist review protocol.
BMJ Open
March 2025
Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Introduction: The number of babies, children and young people with complex care needs (henceforth children with complex care needs (CCCN)) in England has increased in recent decades, and this has also been recognised globally. CCCN may have frequent and lengthy hospital admissions, but during these episodes, their needs are not always met, potentially resulting in suboptimal experiences and outcomes. Despite increased numbers of CCCN accessing acute care and displaying greater complexity, much of the contemporary literature has focused on primary care coordination between health, education and social care.
View Article and Find Full Text PDFUnderstanding the expectations, positions and ambitions of LMICs during pandemic treaty negotiations, and the factors contributing to them.
PLOS Glob Public Health
March 2025
Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
Global South countries account for two-thirds of WHO Member States and are a crucial voice in negotiating the 'pandemic treaty', which Member States agreed was necessary if the world was to avoid a repeat of the significant inequity that resulted during COVID-19. The negotiation of a pandemic treaty presents an opportunity to recalibrate global health systems and processes for pandemic prevention, preparedness and response. However, for this to eventuate through global solidarity, as many Global South countries have said they expect, then concessions by developed states on issues that they have long protected must occur.
View Article and Find Full Text PDFIndividualized Hyaluronidase-Facilitated Subcutaneous Immunoglobulin 10% Administration in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: The Nurse's Role.
J Infus Nurs
March 2025
Author Affiliations: Takeda Development Center Americas, Inc., Cambridge, Massachusetts (Kim Duff); IQVIA Clinical Research Organization, Milan, Italy (Arianna Soresini); IQVIA Clinical Research Organization, Cambridge, Massachusetts (Nancy Wolf* and Alane Fairchild); IQVIA Clinical Research Organization, Ankara, Turkey (Şükran Altan**); IQVIA Clinical Research Organization, Mexico City, Mexico (Wendy Bencomo); University Clinical Center of Serbia, Belgrade, Serbia (Ivana Ivankovic); University Health Network, University of Toronto, Toronto, Ontario, Canada (Evelyn Sarpong); IQVIA Clinical Research Organization, Warsaw, Poland (Anna Kuczkowska).
Hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% offers potential improvements in patient independence and tolerability versus intravenous immunoglobulin (IVIG) when used for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). fSCIG 10% also requires less frequent infusions and fewer infusion sites than conventional subcutaneous immunoglobulin (subcutaneous immunoglobulin without hyaluronidase). The ADVANCE-CIDP 1 study demonstrated fSCIG 10% efficacy and safety in preventing CIDP relapse and positive responses from patients in terms of satisfaction and treatment preference.
View Article and Find Full Text PDFPreserving the Biologically Coherent Generic Concept of , 'Plant Destroyer'.
Phytopathology
March 2025
Mendel University in Brno, Phytophthora Research Centre, Department of Forest Protection and Wildlife Management, Faculty of Forestry and Wood Technology, Zemědělská 3, 613 00 Brno, Brno, Czech Republic, 613 00;
is a long-established, well known and globally important genus of plant pathogens. Phylogenetic evidence has shown that the biologically distinct, obligate biotrophic downy mildews evolved from at least twice. Since, cladistically, this renders 'paraphyletic', it has been proposed that evolutionary clades be split into multiple genera (Runge et al.
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