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http://dx.doi.org/10.1103/physreva.40.35 | DOI Listing |
Science
November 2024
Department of Physics, Harvard University, Cambridge, MA, USA.
Biomed Pharmacother
December 2024
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby 2800, Denmark. Electronic address:
Understanding the molecular mechanisms governing transfection efficiency and particle secretion in high cell density cultures is critical to overcome the cell density effect upon transient gene expression. The effect of different conditioned media in HEK293 transcriptome at low and high cell density is explored. A systematic pair-wise comparative study was performed to shed light on the effect on previous phenotypical characteristics of different media conditions: fresh, exhausted and media depleted from extracellular vesicles (EVs) as well as associated proteins and RNAs.
View Article and Find Full Text PDFISME J
January 2024
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266404, Shandong Province, China.
Diatom bloom is characterized by a rapid increase of population density. Perception of population density and physiological responses can significantly influence their survival strategies, subsequently impacting bloom fate. The population density itself can serve as a signal, which is perceived through chemical signals or chlorophyll fluorescence signals triggered by high cell density, and their intracellular signaling mechanisms remain to be elucidated.
View Article and Find Full Text PDFSci Rep
December 2023
School of Pharmaceutical Science and Technology, Tianjin University, Nankai District, 92 Weijin Road, Tianjin, 300072, China.
The contact inhibition of proliferation (CIP) denotes the cell density-dependent inhibition of growth, and the loss of CIP represents a hallmark of cancer. However, the mechanism by which CIP regulates gene expression remains poorly understood. Chromatin is a highly complex structure consisting of DNA, histones, and trans-acting factors (TAFs).
View Article and Find Full Text PDFBull Math Biol
September 2023
Department of Mathematics, Norwegian University of Life Sciences, Drøbakveien 31, 1432, Ås, Norway.
We investigate biomass-herbivore-carnivore (top predator) interactions in terms of a tritrophic dynamical systems model. The harvesting rates of the herbivores and the top predators are described by means of a sigmoidal function of the herbivores density and the top predator density, respectively. The main focus in this study is on the dynamics as a function of the natural mortality and the maximal harvesting rate of the top predators.
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