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Exploring the Unique Properties and Superior Schwann Cell Guiding Abilities of Spider Egg Sac Silk.
ACS Appl Bio Mater
January 2025
Institute of Physics and Materials Science, Department of Natural Sciences and Sustainable Ressources, BOKU University, Peter Jordan-Straß 82, 1190 Vienna, Austria.
Spider silk (SPSI) is a promising candidate for use as a filler material in nerve guidance conduits (NGCs), facilitating peripheral nerve regeneration by providing a scaffold for Schwann cells (SCs) and axonal growth. However, the specific properties of SPSI that contribute to its regenerative success remain unclear. In this study, the egg sac silk of is investigated, which contains two distinct fiber types: tubuliform (TU) and major ampullate (MA) silk.
View Article and Find Full Text PDFLocal Structure Regulation for Oxygen Redox and Structure Stability of P2-Type Cathodes.
Small
January 2025
Materials Genome Institute, Shanghai University, Shanghai, 200444, China.
The local structure plays a crucial role in oxygen redox reactions, which boosts the capacity of layered oxide cathodes for sodium-ion batteries. While studies on local structural ordering have primarily focused on the intra-layer ordering, there has been limited research on the inter-layer stacking for the layered cathode materials for sodium-ion batteries. In this work, the impact of the intra-layer and inter-layer local structural regulation on anionic kinetics and the structure stability are explored through experimental analysis and theoretical calculations.
View Article and Find Full Text PDFSynchrotron X-ray Fluorescence Microscopy Reveals Trace Elemental Indicators of Life History in Marsupial Teeth.
Biol Trace Elem Res
January 2025
School of Biological Sciences, Monash University, Melbourne, VIC, 3800, Australia.
As teeth develop, their mineralised composition is a bio-recorder of diet, environment, and growth. High-resolution elemental mapping provides a tool to reveal records of life history within teeth. The relative concentrations of a range of trace elements change between in utero development, birth, and weaning in eutherian mammals.
View Article and Find Full Text PDFBiofabricated 3D Intestinal Models as an Alternative to Animal-Based Approaches for Drug Toxicity Assays.
Tissue Eng Regen Med
January 2025
Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Sao Paulo, 13083-100, Brazil.
Background: The main challenge in new drug development is accurately predicting the human response in preclinical models.
Methods: In this study, we developed three different intestinal barrier models using advanced biofabrication techniques: (i) a manual model containing Caco-2 and HT-29 cells on a collagen bed, (ii) a manual model with a Caco-2/HT-29 layer on a HDFn-laden collagen layer, and (iii) a 3D bioprinted model incorporating both cellular layers. Each model was rigorously tested for its ability to simulate a functional intestinal membrane.
Time-resolved spectroscopy uncovers deprotonation-induced reconstruction in oxygen-evolution NiFe-based (oxy)hydroxides.
Nat Commun
January 2025
National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, PR China.
Transition-metal layered double hydroxides are widely utilized as electrocatalysts for the oxygen evolution reaction (OER), undergoing dynamic transformation into active oxyhydroxides during electrochemical operation. Nonetheless, our understanding of the non-equilibrium structural changes that occur during this process remains limited. In this study, utilizing in situ energy-dispersive X-ray absorption spectroscopy and machine learning analysis, we reveal the occurrence of deprotonation and elucidate the role of incorporated iron in facilitating the transition from nickel-iron layered double hydroxide (NiFe LDH) into its active oxyhydroxide.
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