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Safe use of inhaled sedation in critically ill patients with invasive mechanical ventilation.
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Servicio de Medicina Intensiva, Hospital Joan XXIII, Tarragona, Spain.
Inhaled sedation uses halogenated drugs (isoflurane and sevoflurane) in a liquid state that, through a vaporizer, change to a gaseous state and reach the patient by the respiratory route. These drugs have a rapid onset of action, with minimal metabolism and elimination takes place almost exclusively through the airways. They do not cause significant tolerance, tachyphylaxis or significant abstinence.
View Article and Find Full Text PDFAge- and Urothelium-related Changes in Hydrogen Sulfide-induced Responses in Mouse Bladder.
J Physiol Investig
January 2025
Department of Pharmacology, Medical Faculty, Cukurova University, Adana, Turkey.
The alterations in bladder function are associated with aging. Hydrogen sulfide (H 2 S) is a gaseous neurotransmitter that is synthesized in the urinary bladder and is suggested to regulate bladder smooth muscle tone. The effects of age and urothelium on the L-cysteine/H 2 S-induced relaxant responses were investigated in young (3-4 months) and aged (23-24 months) mice.
View Article and Find Full Text PDFEnergy relaxation of N2O in gaseous, supercritical, and liquid xenon and SF6.
J Chem Phys
November 2024
Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.
Rotational and vibrational energy relaxation (RER and VER) of N2O embedded in xenon and SF6 environments ranging from the gas phase to the liquid, including the supercritical regime, is studied at a molecular level. Calibrated intermolecular interactions from high-level electronic structure calculations, validated against experiments for the pure solvents, were used to carry out classical molecular dynamics simulations corresponding to experimental state points for near-critical isotherms. The computed RER rates in low-density solvents of krotXe=(3.
View Article and Find Full Text PDFRelaxation of Methane in Mixtures with Gaseous Water.
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June 2024
Chemical Process Engineering (CVT), Faculty of Production Engineering, University of Bremen, Leobener Strasse 6, 28359 Bremen, Germany.
Synthetic, ecofriendly fuels and chemicals can be produced through Power-To-X (PtX) processes. To study such catalytic processes operando and spatially resolved, magnetic resonance imaging (MRI) is a versatile tool. A main issue in the application of MRI in reactive studies is a lack of knowledge about how the gathered signals can be interpreted into reaction data like temperature or species concentration.
View Article and Find Full Text PDFTherapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders.
Biomolecules
April 2024
Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, No. 24, Heping Street, Harbin 150040, China.
Hydrogen sulfide (HS), previously regarded as a toxic exhaust and atmospheric pollutant, has emerged as the third gaseous signaling molecule following nitric oxide (NO) and carbon monoxide (CO). Recent research has revealed significant biological effects of HS in a variety of systems, such as the nervous, cardiovascular, and digestive systems. Additionally, HS has been found to impact reproductive system function and may have therapeutic implications for reproductive disorders.
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