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Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Medical University of South Carolina, Charleston, SC, USA.
Background: Repetitive transcranial magnetic stimulation enhances cognition in people with mild cognitive impairment (MCI). Whereas conventional treatment requires daily sessions for 4-6 weeks, accelerated intermittent theta burst stimulation (iTBS) shortens the treatment course to just 3 days, substantially improving feasibility of use in people with MCI. We conducted a Phase I safety and feasibility trial of iTBS in MCI, finding preliminary evidence of cognitive improvement.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
Clinic of Cardiovascular Diseases named after Most Holy John Tobolsky, Moscow, Moscow, Russia.
Background: Most cerebrovascular lesions are aggravated by dementia. This study examines the possibility of reducing dementia by stimulating cerebral angiogenesis and neurogenesis using Transcatheter Intracerebral Laser Photobiomodulation Therapy (PBMT) in patients with Alzheimer's disease (AD), distal cerebral atherosclerosis, Binswanger's disease (BD), and vascular parkinsonism (VP).
Methods: The study included 404 patients with dementia, aged 29-81 (mean age 78).
Bilateral Ovarian Agenesis and Bone Modeling Disease in Pre-puberty Girl With Primary Amenorrhea.
Cureus
December 2024
Department of Obstetrics and Gynecology, Royal Medical Services, Amman, JOR.
Ovarian agenesis (OA) is a rare congenital condition characterized by the absence of one or both ovaries, often associated with chromosomal abnormalities, hormonal imbalances, and structural deformities. The condition is frequently diagnosed in females presenting with primary amenorrhea and delayed sexual development. This case report highlights a unique presentation of bilateral ovarian agenesis in a patient with chromosome X translocation, bone modeling disease, and primary amenorrhea.
View Article and Find Full Text PDFThe impact of transcutaneous vagus nerve stimulation on anterior cingulate cortex activity in a cognitive control task.
Psychophysiology
January 2025
Biological Psychology Lab, Department of Psychology, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Transcutaneous vagus nerve stimulation (tVNS) offers a non-invasive method to enhance noradrenergic neurotransmission in the human brain, thereby increasing cognitive control. Here, we investigate if changes in cognitive control induced by tVNS are mediated through locus coeruleus-induced modifications of neural activity in the anterior cingulate cortex. Young healthy participants engaged in a simple cognitive control task focusing on response inhibition and a more complex task that involved both response inhibition and working memory, inside a magnetic resonance imaging scanner.
View Article and Find Full Text PDFInvestigating Neurometabolite Changes in Response to Median Nerve Stimulation.
Brain Behav
January 2025
School of Psychology, University of Nottingham University Park, Nottingham, UK.
Background: Rhythmic median nerve stimulation (MNS) at 10 Hz has been shown to cause a substantial reduction in tic frequency in individuals with Tourette syndrome. The mechanism of action is currently unknown but is hypothesized to involve entrainment of oscillations within the sensorimotor cortex.
Objective: We used functional magnetic resonance spectroscopy (fMRS) to explore the dynamic effects of MNS on neurometabolite concentrations.
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